SARS-CoV-2 and Stroke in a New York Healthcare System
SARS-CoV-2 and Stroke in a New York Healthcare System
复制标题
DOI：
10.1161/strokeaha.120.030335
复制
发表时间：
2020-07-01
期刊：
影响因子：
8.3
通讯作者：
Frontera, Jennifer
中科院分区：
文献类型：
--
作者：
Yaghi, Shadi;Ishida, Koto;Frontera, Jennifer
背景与目的：随着2019冠状病毒病（COVID-19）在当前全球大流行期间的传播，越来越多的证据表明，受该疾病影响的患者可能出现临床显著的凝血功能障碍，并伴有缺血性卒中等血栓栓塞性并发症。然而，关于卒中合并COVID-19患者的临床特征、卒中机制和结局的数据有限。方法：我们对2020年3月15日至2020年4月19日期间住院的连续缺血性卒中患者进行了一项回顾性队列研究，这些患者在纽约的一个主要卫生系统中住院，纽约是目前全球大流行的震中。我们比较了同时诊断COVID-19的脑卒中患者与未诊断COVID-19的脑卒中患者（同期对照）的临床特征。此外，我们将患者与2019年3月15日至2019年4月15日从我们医院系统出院的缺血性卒中患者的历史队列（历史对照）进行了比较。结果：2020年研究期间，在3556例诊断为COVID-19感染的住院患者中，32例（0.9%）影像学证实为缺血性卒中。与同时代对照组（30.4%，P=0.003）和历史对照组（25.0%,P =0.003）相比，新冠肺炎患者中隐源性卒中（65.6%）更为常见
Background and Purpose: With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. However, there is limited data on the clinical characteristics, stroke mechanism, and outcomes of patients who have a stroke and COVID-19. Methods: We conducted a retrospective cohort study of consecutive patients with ischemic stroke who were hospitalized between March 15, 2020, and April 19, 2020, within a major health system in New York, the current global epicenter of the pandemic. We compared the clinical characteristics of stroke patients with a concurrent diagnosis of COVID-19 to stroke patients without COVID-19 (contemporary controls). In addition, we compared patients to a historical cohort of patients with ischemic stroke discharged from our hospital system between March 15, 2019, and April 15, 2019 (historical controls). Results: During the study period in 2020, out of 3556 hospitalized patients with diagnosis of COVID-19 infection, 32 patients (0.9%) had imaging proven ischemic stroke. Cryptogenic stroke was more common in patients with COVID-19 (65.6%) as compared to contemporary controls (30.4%,P=0.003) and historical controls (25.0%,P