Neuroendocrine neoplasms of the gastrointestinal tract: Classification, pathologic basis, and imaging features
Neuroendocrine neoplasms of the gastrointestinal tract: Classification, pathologic basis, and imaging features
复制标题
DOI：
10.1148/rg.276075001
复制
发表时间：
2007-11-01
期刊：
影响因子：
5.5
通讯作者：
Jang, Kee-Taek
中科院分区：
文献类型：
--
作者：
Chang, Samuel;Choi, Dongil;Jang, Kee-Taek
许多放射科医生不熟悉世界卫生组织最近制定的神经内分泌肿瘤分类方案。根据该分类方案，神经内分泌肿瘤根据其位置、组织学特征和生物学行为分为高分化内分泌肿瘤（类癌）、高分化内分泌癌（恶性类癌）和低分化内分泌癌。大多数神经内分泌肿瘤具有非特异性的影像学特征。然而，它们有时具有特殊的临床表现和放射学特征，放射科医生可以根据这些特征推断具体的诊断。胃肠道神经内分泌肿瘤起源于胚胎神经嵴、神经外胚层和内胚层的细胞。它们通常产生生物活性物质并对神经内分泌标记物显示免疫反应性。虽然神经内分泌肿瘤并不常见，但在有典型综合征或肿瘤具有特征性影像学特征的患者中，在制定胃肠道肿瘤的鉴别诊断时应考虑神经内分泌肿瘤。(C)RSNA，2007年
Many radiologists are unfamiliar with the recently developed World Health Organization classification scheme for neuroendocrine tumors. According to this classification scheme, neuroendocrine tumors are divided into well-differentiated endocrine tumors (carcinoids), well-differentiated endocrine carcinomas (malignant carcinoids), and poorly differentiated endocrine carcinomas on the basis of their location, histologic features, and biologic behavior. Most neuroendocrine tumors have nonspecific imaging characteristics. However, they sometimes have peculiar clinical manifestations and radiologic features, on the basis of which radiologists may infer the specific diagnosis. Neuroendocrine tumors of the gastrointestinal tract originate from the cells derived from the embryonic neural crest, neuroectoderm, and endoderm. They usually produce bioactive substances and show immunoreactivity to neuroendocrine markers. Although neuroendocrine tumors are uncommon, they should be considered in developing the differential diagnosis for gastrointestinal tumors in patients with a typical syndrome or when the tumors have characteristic imaging features. (C) RSNA, 2007