Photopolymerized phospholipid vesicles Stability and retention of hydrophilic and hydrophobic marker substances
Photopolymerized phospholipid vesicles Stability and retention of hydrophilic and hydrophobic marker substances
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光聚合磷脂囊泡 亲水性和疏水性标记物质的稳定性和保留
DOI：
10.1016/0005-2736(84)90118-4
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
M. Singh
中科院分区：
文献类型：
--
作者：
R. Juliano;M. Hsu;S. Regen;M. Singh
磷脂酰胆碱的光聚合类似物形成了多层囊泡。聚合囊泡在机械和化学扰动下的稳定性明显不同于传统囊泡。因此，聚合囊泡，而不是传统的囊泡，在超声波或暴露于有机溶剂或洗涤剂后，保持其整体的物理完整性。用十二烷基硫酸钠等洗涤剂处理光聚合囊泡，可释放被包裹的亲水性溶质；然而，在常规囊泡完全溶解的情况下，聚合囊泡保留了亲脂性溶质。因此，光聚合磷脂膜代表了混合实体，它似乎混合了传统脂质双分子层的一些特征和更典型的聚合物膜的特性。
Multilamellar vesicles were formed from photopolymerizable analogs of phosphatidylcholine. The polymerized vesicles differed markedly from conventional vesicles in terms of their stability to mechanical and chemical perturbations. Thus, polymerized vesicles, but not conventional ones, retained their overall physical integrity subsequent to ultrasonication or to exposure to organic solvents or detergents. Treatment of photopolymerized vesicles with detergents such as sodium dodecyl sulfate caused the release of entrapped hydrophilic solutes; however, lipophilic solutes were retained by the polymerized vesicles under circumstances in which conventional vesicles were completely solubilized. Thus, photopolymerized phospholipid membranes represent hybrid entities which seem to blend some of the characteristics of conventional lipid bilayers with properties more typical of polymer membranes.