On the adaptive structures of the collagen fibrils of bone and cartilage.
On the adaptive structures of the collagen fibrils of bone and cartilage.
复制标题
关于骨和软骨的胶原原纤维的适应性结构。
DOI：
10.1016/0021-9290(91)90378-z
复制
发表时间：
1991
影响因子：
2.4
通讯作者：
Katz,EP
中科院分区：
文献类型：
--
作者：
Volpi,M;Katz,EP
为了研究骨和软骨如何在分子水平上响应骨骼需求的变化，通过 X 射线衍射研究了 2 至 14 岁奶牛股骨关节软骨中内源性和外部化学应力对胶原纤维结构的影响（作为局部函数）。发现原纤维被邻近的蛋白聚糖渗透压缩。对于大多数部位，分子堆积密度在关节表面较小，并在邻近骨处增加至最大值。随着动物年龄的增长，这种结构梯度变得更加突出。对于所有年龄段，在酶法去除蛋白多糖后，堆积密度梯度几乎可以完全消除。然而，在运动中承受最大压力的软骨区域，原纤维具有过度肿胀的结构。这种过度肿胀的倾向随着动物年龄的增长而增加。我们得出的结论是，关节软骨中的胶原纤维适应了一种响应其各自机械化学历史的结构。
In order to investigate how bone and cartilage respond at the molecular level to changing demands of the skeleton, the influence of endogenous and external chemical stresses on collagen fibrillar structure as a function of locale in the femoral articular cartilage from 2 to 14 year old cows has been studied by x-ray diffraction. The fibrils were found to be osmotically compressed by vicinal proteoglycans. For most locales, the molecular packing density was less at the articular surface and increased to a maximum adjacent to the bone. This gradient in structure became more accentuated with animal age. For all ages, the packing density gradients could be almost completely eliminated upon enzymatic removal of the proteoglycans. However, in the regions of cartilage which had experienced the greatest stress in locomotion, the fibrils had a hyperswollen structure. This tendency towards hyperswelling increased with animal age. We have concluded that the collagen fibrils in articular cartilage adapt a structure that is in response to their respective mechanico-chemical histories.