Characterization, synthesis and self-aggregation of (-)-alternarlactam: a new fungal cytotoxin with cyclopentenone and isoquinolinone scaffolds.
Characterization, synthesis and self-aggregation of (-)-alternarlactam: a new fungal cytotoxin with cyclopentenone and isoquinolinone scaffolds.
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DOI：
10.1002/chem.201002205
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发表时间：
2010-12
期刊：
影响因子：
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通讯作者：
A. Zhang;Nan Jiang;W. Gu;Jing Ma;Yu Rong Wang;Y. Song;R. Tan
中科院分区：
文献类型：
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作者：
A. Zhang;Nan Jiang;W. Gu;Jing Ma;Yu Rong Wang;Y. Song;R. Tan
（-）-交链孢内酰胺[（-）-1]是一种新的有前途的抗两种人癌细胞系的细胞毒素，从内生菌培养物中分离并由容易获得的起始原料合成（沿着（+）-1）。结合合成、光谱和计算方法，确定了（-）-1的绝对构型、手性活性相关性和自聚集性。新的真菌细胞毒素的全面表征可能为发现新的抗肿瘤药物提供有价值的信息。
(-)-Alternarlactam [(-)-1], a new promising cytotoxin against two human cancer cell lines, was isolated from an endophyte culture and synthesized (along with (+)-1) from readily available starting materials. The absolute configuration, chirality-activity relevance and self-aggregation of (-)-1 were assigned by a combination of synthetic, spectroscopic and computational approaches. The full characterization of the new fungal cytotoxin may provide valuable information in the discovery of new antitumor agents.