Elevated anti-malarial IgE in asymptomatic individuals is associated with reduced risk for subsequent clinical malaria
Elevated anti-malarial IgE in asymptomatic individuals is associated with reduced risk for subsequent clinical malaria
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DOI：
10.1016/j.ijpara.2004.04.007
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发表时间：
2004-07-01
影响因子：
4
通讯作者：
Färnert, A
中科院分区：
文献类型：
--
作者：
Bereczky, S;Montgomery, SM;Färnert, A
免疫学特征评估临床疟疾的前瞻性风险在纵向跟踪人口在坦桑尼亚的全流行区。基线特征包括恶性疟原虫粗提取物特异性IgE和IgG；总IgE;对700例无症状人群进行恶性疟原虫克隆数等寄生虫学指标调查。Cox回归分析估计了在40周的随访期间发生新的临床发作的风险。anti-P高。在所有年龄组中，恶性疟原虫IgE水平与急性疟疾风险降低相关，与总IgE水平无关。校正年龄、性别、总IgE、每次感染的寄生虫克隆数和HIV-1血清阳性后，两个最高的五分之二的比值比分别为0.26 （95% CL 0.09-0.72, P = 0.010）和0.44 (95% CI 0.19-0.99, P = 0.047)，统计学上有显著降低。相比之下，高水平的疟疾特异性IgG或总IgE与发生新的临床发作的风险降低无关。无症状多克隆恶性疟原虫感染的保护作用也得到证实。首次发现流行地区无症状个体抗疟疾IgE水平与后续疟疾发病风险降低相关。特异性IgE抗体可能在维持抗疟疾免疫中发挥作用，或表明与疟疾保护相关的免疫功能的其他方面。(C) 2004澳大利亚寄生虫学学会Elsevier Ltd.出版。版权所有。
Immunological characteristics were assessed for prospective risk of clinical malaria in a longitudinally followed population in a holoendemic area of Tanzania. Baseline characteristics including crude Plasmodium falciparum extract-specific IgE and IgG; total IgE; and parasitological indices, e.g. number of P. falciparum clones, were investigated among 700 asymptomatic individuals. Cox regression analysis estimated the risk of succumbing to a new clinical episode during a 40 weeks follow up. High anti-P. falciparum IgE levels were associated with reduced risk of acute malaria in all age groups independently of total IgE levels. Statistically significant reduced odds ratio of 0.26 (95% CL 0.09-0.72, P = 0.010) and 0.44 (95% CI, 0.19-0.99, P = 0.047) for the two highest fifths, respectively was observed after adjustment for age, sex, total IgE, numbers of parasite clones per infection and HIV-1 seropositivity. In contrast, high levels of malaria specific IgG or total IgE were not associated with reduced risk to succumb to a new clinical episode. A protective effect of asymptomatic multiclonal P. falciparum infections was also confirmed. For the first time, anti-malarial IgE levels in asymptomatic individuals in endemic area are found to be associated with reduced risk for subsequent malaria disease. Specific IgE antibodies may play role in maintaining anti-malarial immunity, or indicate other aspects of immune function relevant for protection against malaria. (C) 2004 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.