Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study
Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study
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DOI：
10.1186/s12199-019-0796-6
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发表时间：
2019-06-10
影响因子：
4.7
通讯作者：
Maeda, Takahiro
中科院分区：
文献类型：
--
作者：
Shimizu, Yuji;Yamanashi, Hirotomo;Maeda, Takahiro
背景我们报道了人T细胞白血病病毒1型（HTLV-1）感染与动脉粥样硬化的关系。最近的证据表明牙周炎与动脉粥样硬化、内皮功能障碍和微循环障碍密切相关。然而，HTLV-1和晚期牙周炎之间的关联迄今尚未调查。由于造血活动是密切相关的内皮细胞的维护活动，并被称为随着年龄的增长而下降，我们假设造血活动的状态影响之间的关联HTLV-1和先进的牙周炎在老年participator.MethodsA横断面研究进行了包括822名老年人参与者年龄在60- 99岁谁参加了牙齿健康检查。晚期牙周炎定义为牙周袋6.0mm。参与者被归类为具有低或高的造血活动，根据网织红细胞的中位数值。ResultsHTLV-1感染与造血活动较低（网织红细胞计数较低）的参与者之间的晚期牙周炎呈正相关，但没有参与者之间的造血活动较高（网织红细胞计数较高）。调整后的优势比（95%置信区间）考虑潜在的混杂因素为1.92（1.05-3.49）的参与者与较低的网织红细胞计数和0.69（0.35-1.36）的参与者与较高的网织红细胞count.ConclusionsAmong老年人参与者，HTLV-1感染和晚期牙周炎之间的关联是造血活动的影响。由于造血活动与内皮细胞的维持有关，这些发现为阐明老年参与者牙周炎进展的潜在机制提供了一个有效的工具。
BackgroundWe reported that human T cell leukemia virus 1 (HTLV-1) infection is positively associated with atherosclerosis. Recent evidence has revealed a close association of periodontitis with atherosclerosis, endothelial dysfunction, and disruption of the microcirculation. However, the association between HTLV-1 and advanced periodontitis has not been investigated to date. Since hematopoietic activity is closely linked to endothelial maintenance activity and is known to decline with age, we hypothesized that the state of hematopoietic activity influenced the association between HTLV-1 and advanced periodontitis in elderly participants.MethodsA cross-sectional study was performed including 822 elderly participants aged 60-99years who participated in a dental health check-up. Advanced periodontitis was defined as a periodontal pocket 6.0mm. Participants were classified as having low or high hematopoietic activity according to the median values of reticulocytes.ResultsHTLV-1 infection was positively related to advanced periodontitis among participants with lower hematopoietic activity (lower reticulocyte count), but not among participants with higher hematopoietic activity (higher reticulocyte count). The adjusted odds ratio (95% confidence interval) considering potential confounding factors was 1.92 (1.05-3.49) for participants with a lower reticulocyte count and 0.69 (0.35-1.36) for participants with a higher reticulocyte count.ConclusionsAmong elderly participants, the association between HTLV-1 infection and advanced periodontitis is influenced by hematopoietic activity. Since hematopoietic activity is associated with endothelial maintenance, these findings provide an efficient tool for clarifying the underlying mechanism of the progression of periodontitis among elderly participants.