Safety of maximal cardiopulmonary exercise testing in individuals with sickle cell disease: a systematic review.
Safety of maximal cardiopulmonary exercise testing in individuals with sickle cell disease: a systematic review.
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镰状细胞病患者最大心肺运动试验的安全性：一项系统性综述。
DOI：
10.1136/bjsports-2021-104450
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发表时间：
2022-07
影响因子：
18.4
通讯作者：
Liem RI
中科院分区：
文献类型：
--
作者：
Smith KN;Baynard T;Fischbach PS;Hankins JS;Hsu LL;Murphy PM;Ness KK;Radom-Aizik S;Tang A;Liem RI
我们评估了最大心肺运动试验（CPET）在镰状细胞病（SCD）患者中的安全性。使用气体交换分析的最大CPET是在实验室中测量心肺功能的金标准，但其在SCD人群中的安全性尚不清楚。系统评价。系统检索Medline（PubMed）、EMBASE、科克伦、ClinicalTrials.gov和专业协会网站，以获得截至2020年12月的所有已发表研究和摘要。两名评审员独立地从研究中提取了感兴趣的数据，这些研究评估了最大CPET在SCD儿童和成人中的安全性结局。使用改良版的Newcastle-Ottawa量表（NOS）评估纳入研究的偏倚风险。共有24项研究符合入选/排除标准。在纳入的研究中，接受最大CPET的SCD受试者中有36/939（3.8%）单独报告或作为研究结果的一部分报告了不良事件。大多数不良事件与心电图（ECG）监测的短暂性缺血性变化或测试期间的氧饱和度下降有关，不会导致心律失常或其他并发症。仅4/939（0.43%）例受试者因最大CPET发生疼痛事件。最大CPET似乎是SCD儿童和成人的安全测试方式，可用于更好地了解运动能力降低的生理基础，并指导该人群的运动处方。一些研究没有重点报告与运动试验相关的不良事件，或者没有提及安全性监测，这导致了偏倚风险。
We evaluated the safety of maximal cardiopulmonary exercise testing (CPET) in individuals with sickle cell disease (SCD). Maximal CPET using gas exchange analysis is the gold standard for measuring cardiopulmonary fitness in the laboratory, yet its safety in the SCD population is unclear. Systematic review. Systematic search of Medline (PubMed), EMBASE, Cochrane, ClinicalTrials.gov and professional society websites for all published studies and abstracts through December 2020. Two reviewers independently extracted data of interest from studies that assessed safety outcomes of maximal CPET in children and adults with SCD. A modified version of the Newcastle-Ottawa Scale (NOS) was used to assess for risk of bias in studies included. In total, 24 studies met inclusion/exclusion criteria. Adverse events were reported separately or as part of study results in 36/939 (3.8%) of participants with SCD undergoing maximal CPET in studies included. Most adverse events were related to transient ischemic changes on electrocardiogram (ECG) monitoring or oxygen desaturation during testing that did not result in arrhythmias or other complications. Only 4/939 (0.43%) participants experienced pain events due to maximal CPET. Maximal CPET appears to be a safe testing modality in children and adults with SCD and can be used to better understand the physiologic basis of reduced exercise capacity as well as guide exercise prescription in this population. Some studies did not focus on reporting adverse events related to exercise testing or failed to mention safety monitoring, which contributed to risk of bias.
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影响因子：
9.6
作者：
Chaudry, Rifat A.;Bush, Andrew;Crowley, Suzanne
通讯作者：
Crowley, Suzanne
影响因子：
6.5
作者：
Liem, Robert I.;Onyejekwe, Kasiemobi;Thompson, Alexis A.
通讯作者：
Thompson, Alexis A.
影响因子：
120.7
作者：
Blair, SN;Kampert, JB;Gibbons, LW
通讯作者：
Gibbons, LW
影响因子：
3.1
作者：
Badawy SM;Payne AB;Rodeghier MJ;Liem RI
通讯作者：
Liem RI
DOI：
10.1164/rccm.2002036
发表时间：
2002-05-01
影响因子：
24.7
作者：
Callahan, LA;Woods, KF;Gutin, B
通讯作者：
Gutin, B