Soft active aggregates: mechanics, dynamics and self-assembly of liquid-like intracellular protein bodies
Soft active aggregates: mechanics, dynamics and self-assembly of liquid-like intracellular protein bodies
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DOI：
10.1039/c0sm00981d
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发表时间：
2011-01-01
期刊：
影响因子：
3.4
通讯作者：
Brangwynne, Clifford P.
中科院分区：
文献类型：
--
作者：
Brangwynne, Clifford P.
胞内小体由浓缩蛋白质和RNA的动态聚集体组成，是活细胞细胞质和细胞核中普遍存在的特征。数十种不同类型的蛋白体参与各种生理过程，包括核糖体生物发生、RNA剪接和细胞分裂。与传统的细胞器不同的是，它们不受包围膜的限制。相反，这些物体代表了局部集中的大分子的动态模式，这些大分子以秒为时间尺度翻转。在这里，我们讨论了最近的研究结果，表明细胞内蛋白体是活跃的液体状滴，在固有结构的细胞质内自组装。
Intracellular bodies consisting of dynamic aggregates of concentrated proteins and often RNA are a ubiquitous feature of the cytoplasm and nucleus of living cells. Dozens of different types of protein bodies are involved in diverse physiological processes including ribosome biogenesis, RNA splicing, and cell division. Unlike conventional organelles, they are not defined by an enclosing membrane. Instead, these bodies represent dynamic patterns of locally concentrated macromolecules which turn over on timescales of seconds. Here we discuss recent findings suggesting that intracellular protein bodies are active liquid-like drops that self-assemble within an intrinsically structured cytoplasm.