Effects of oximes on mitochondrial oxidase activity
Effects of oximes on mitochondrial oxidase activity
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DOI：
10.1016/j.toxlet.2009.05.007
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发表时间：
2009-09-10
影响因子：
3.5
通讯作者：
Watanabe, Ken
中科院分区：
文献类型：
--
作者：
Sakurada, Koichi;Ikegaya, Hiroshi;Watanabe, Ken
肟类化合物，包括2-吡啶醛肟甲碘化物（2-PAM），是乙酰胆碱酯酶（AChE）的重激活剂。不幸的是，它们的临床应用受到其毒性的限制。为了研究这种毒性的机制，肟对线粒体呼吸链的胆碱氧化酶（ChOD）和细胞色素c氧化酶（CyCOD）的影响进行了研究。肟类化合物2-PAM、双肟和二乙酰一肟的含量显著高于对照组（P
Oximes, including 2-pyridinealdoxime methiodide (2-PAM), are reactivators of acetylcholinesterase (AChE) inhibited by organophosphate poisoning. Unfortunately, their clinical use has been limited by their toxicity. To investigate the mechanism of this toxicity, the effects of oximes on the enzymes choline oxidase (ChOD) and cytochrome c oxidase (CyCOD) of the respiratory chain in mitochondria were examined. The oximes 2-PAM, obidoxime, and diacetylmonoxime significantly (P