Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology
Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology
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CLL 向 ALCL 的转变：克隆性研究在分子血液病理学诊断中的作用
DOI：
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发表时间：
2016
影响因子：
0.6
通讯作者：
E. Soilleux
中科院分区：
文献类型：
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作者：
R. Colling;D. Royston;E. Soilleux
克隆性研究极大地帮助诊断具有挑战性的血液病理病例。这些强大的和标准化的测试有助于克隆淋巴细胞群体的检测，并可能有助于淋巴细胞分型。在这个病例报告中，一位先生表现为B细胞肿瘤的高级别转化，其组织学和免疫表型模拟了T细胞间变性大细胞淋巴瘤。借助T细胞和B细胞受体克隆性研究，证明该肿瘤实际上是B细胞谱系。本报告举例说明了这些越来越多使用和相对较新的分子检测在罕见和困难的淋巴瘤表现中的作用，并强调了在解释其结果时可能存在的缺陷。
Clonality studies greatly assist in the diagnosis of challenging haematopathology cases. These robust and standardised tests aid the detection of clonal lymphoid populations and may assist in lymphocyte subtyping. In this case report, a gentleman presented with a high-grade transformation of a B cell neoplasm which histologically and immunophenotypically mimicked a T cell anaplastic large-cell lymphoma. With the aid of T cell and B cell receptor clonality studies, it was demonstrated that this tumour was in fact of B cell lineage. This report exemplifies the role of these increasingly used and relatively new molecular tests in unusual and difficult lymphoma presentations and highlights potential pitfalls in the interpretation of their results.