Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer
Co-expression of ERCC1 and Snail is a prognostic but not predictive factor of cisplatin-based neoadjuvant chemotherapy for bladder cancer
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DOI：
10.3892/ol.2012.689
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发表时间：
2012-07-01
期刊：
影响因子：
2.9
通讯作者：
Tsujimura, Akira
中科院分区：
文献类型：
--
作者：
Kawashima, Atsunari;Takayama, Hitoshi;Tsujimura, Akira
膀胱癌新辅助化疗（NC）已被报道可显著提高5年生存率。本研究旨在探讨ERCC1和Snail在决定膀胱癌NC和根治性化疗（RC）对化疗反应中的作用。采用免疫组化法检测58例膀胱肿瘤患者经NC和RC治疗后Snail和ERCC1蛋白的表达。研究Snail和ERCC1表达与临床反应的相关性。Snail和ERCC1在58例患者中共表达24例（41.4%）。Snail与ERCC1的表达有显著相关性（P = 0.001）。Snail和ERCC1的共表达不能预测病理完全缓解（P = 0.202）。单因素分析结果显示，Snail和ERCC1共表达者的无病生存期（DFS）和总生存期（OS）均短于Snail和/或ERCC1阴性表达者。ERCC1和Snail共表达是无病生存率（P = 0.029）和总生存率（P = 0.040）的唯一预测因子。Snail和ERCC1的表达相关，二者共表达是NC和RC治疗后DFS和OS缩短的唯一显著预测因素。
Neoadjuvant chemotherapy (NC) for bladder cancer has been reported to significantly improve the 5-year survival rate. The aim of the present study was to examine the roles of ERCC1 and Snail in determining the response to chemotherapy in bladder cancer treated with NC and radical cystectomy (RC). The expression of the Snail and ERCC1 proteins was determined by immunohistochemical staining of specimens obtained from 58 patients with bladder tumors treated with NC and RC. The correlation between clinical response and the expression of Snail and ERCC1 was investigated. Snail and ERCC1 were co-expressed in 24 (41.4%) of the 58 patients. A marked correlation was found between the expression of Snail and ERCC1 (P=0.001). The co-expression of Snail and ERCC1 was not able to predict pathological complete response (P=0.202). Results of the univariate analysis revealed that the co-expression of Snail and ERCC1 predicted shorter disease-free survival (DFS) and overall survival (OS) than the negative expression of Snail and/or ERCC1. Moreover, the co-expression of ERCC1 and Snail was the only predictive factor for both DFS (P=0.029) and OS (P=0.040). The expression of Snail was correlated with that of ERCC1 and the co-expression of Snail and ERCC1 was the only significant predictive factor of shorter DFS and OS in patients with bladder cancer treated with NC and RC.