Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs
Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs
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DOI：
10.1016/j.jconrel.2006.06.015
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发表时间：
2006-08-28
影响因子：
10.8
通讯作者：
Bronich, Tatiana K.
中科院分区：
文献类型：
--
作者：
Bontha, Satya;Kabanov, Alexander V.;Bronich, Tatiana K.
这项工作报告的设计与交联的离子核心，显示高稳定性的聚合物胶束。聚（环氧乙烷）-b-聚（甲基丙烯酸）共聚物和二价金属阳离子的嵌段离聚物复合物被用作胶束模板的合成的交联胶束。这样的胶束代表核-壳形态的亲水性纳米球。核包括交联聚阴离子的网络，其被亲水性PEO链的壳包围。核心的离子特性提供了纳米凝胶的pH依赖性溶胀/塌陷行为。顺铂，一种有效的化疗剂，被纳入胶束的离子核心，具有显着的高效率（22%w/w）。载药胶束在水性分散体中稳定，长时间不发生聚集或沉淀。在生理盐水中，铂络合物以持续的方式从载顺铂的交联胶束中缓慢释放。使用人卵巢癌A2780细胞的体外研究表明，交联胶束迅速内化并将顺铂递送到细胞中。这些结果表明，具有交联离子核的聚合物胶束是有希望的基础材料研究和实际应用作为药物释放载体。(c)2006 Elsevier B. V.保留所有权利。
This work reports the design of polymer micelles with cross-linked ionic cores that display high stability. Block ionomer complexes of poly (ethylene oxide)-b-poly(methacrylic acid) copolymer and divalent metal cations were utilized as micellar templates for the synthesis of the crosslinked micelles. Such micelles represent hydrophilic nanospheres of core-shell morphology. The core comprises a network of the cross-linked polyanions, which is surrounded by the shell of hydrophilic PEO chains. The ionic character of the core provided for pH-dependent swelling/collapse behavior of the nanogels. Cisplatin, a potent chemotherapeutic agent, was incorporated into the ionic core of the micelles with remarkably high efficiency (22% w/w). The drug-loaded micelles were stable in aqueous dispersions exhibiting no aggregation or precipitation for a prolonged period of time. Slow release of platinum complexes was observed in sustained manner from the cisplatin-loaded cross-linked micelles in physiological saline. In vitro studies using human A2780 ovarian carcinoma cells demonstrated that the cross-linked micelles rapidly internalized and delivered cisplatin into cells. These results indicated that polymer micelles with cross-linked ionic cores are promising for further fundamental material studies and practical applications as drug delivery carriers. (c) 2006 Elsevier B.V. All rights reserved.