Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor
Recognition of Mycobacteria by Dendritic Cell Immunoactivating Receptor
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树突状细胞免疫激活受体对分枝杆菌的识别
DOI：
10.1007/82_2020_203
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发表时间：
2020
影响因子：
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通讯作者：
Yamasaki S.
中科院分区：
文献类型：
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作者：
Toyonaga K;Yamasaki S.
分枝杆菌的细胞壁上具有独特的脂质，这些脂质组分的结构和生理活性一直是许多研究的主题。尽管分枝杆菌脂质的宿主受体长期以来一直是难以捉摸的，但近年来已报道C型凝集素受体（CLRs）识别这些组分。树突状细胞免疫活化受体（DCAR）是由Clec4b1基因编码的一种树突状细胞免疫活化受体。DCAR于2003年被鉴定，据报道与含有免疫受体酪氨酸激活基序（ITAM）的衔接蛋白Fc受体γ链（FcRγ）相关。但其生理配体和生物学功能尚不清楚。我们最近发现DCAR是分枝杆菌的激活受体。DCAR识别分枝杆菌中的酰化磷脂酰肌醇甘露糖苷（PIM），以促进分枝杆菌感染期间的Th1应答。本文就DCAR的配体及其免疫学作用的研究进展作一综述。
Mycobacteria have unique lipids on their cell walls, and the structures and physiological activities of these lipid components have been the subject of many studies. Although the host receptors for mycobacterial lipid have long been elusive, in recent years C-type lectin receptors (CLRs) have been reported to recognize these components. The dendritic cell immunoactivating receptor (DCAR), a CLR member, is encoded byClec4b1. DCAR, which was identified in 2003, is reported to be associated with the immunoreceptor tyrosine-based activation motif (ITAM)-containing adaptor protein, the Fc receptor γ chain (FcRγ). However, its physiological ligand and biological function were unknown. We recently identified DCAR as an activating receptor for mycobacteria. DCAR recognizes acylated phosphatidyl-inositol mannosides (PIMs) in mycobacteria to promote Th1 responses during mycobacterial infection. This review summarizes recent discoveries about the ligands and immunological roles of DCAR.