A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells
A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells
复制标题
一种新型 Bcl-XL 抑制剂 Z36 可诱导 Hela 细胞自噬细胞死亡
DOI：
10.4161/auto.5.3.7888
复制
发表时间：
2009-04-01
期刊：
影响因子：
13.3
通讯作者：
Xia, Bin
中科院分区：
文献类型：
--
作者：
Lin, Jian;Zheng, Zhibin;Xia, Bin
Inhibition of Bcl2 family proteins Bcl-XL and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-XL inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.
