Search for Oral Medicine That Might Exacerbate the Prognosis of Adverse Drug Events in Elderly Patients
Search for Oral Medicine That Might Exacerbate the Prognosis of Adverse Drug Events in Elderly Patients
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寻找可能加剧老年患者药物不良事件预后的口服药物
DOI：
10.11256/jjdi.18.277
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
寺町 ひとみ
中科院分区：
文献类型：
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作者：
野口 義紘; 林 勇汰; 吉田 阿希; 杉田 郁人; 江崎 宏樹; 齊藤 康介; 臼井 一将; 加藤 未紗; 舘 知也; 寺町 ひとみ
目的：老年患者由于药物代谢和排泄能力差，常发生药物不良事件(ADE)，常导致多器官功能障碍综合征。因此，在预后的早期识别药物不良事件是很重要的。我们检索可能加重老年ADE患者预后的口服药物。方法：分析对象为日本药品不良事件报告数据库(JADER)注册的口服药物。用危险比(RR)分析老年/非老年患者与急性加重风险/非恶化风险的关系。恶化风险的信号检测定义为风险比下限>；1和χ2≥4的95%可信区间。<；br>；结果：与年轻患者的ADE相比，可能显著加重老年患者ADE预后的口服药物包括84项，其中63项在所有老年患者的医疗指南中没有被描述为潜在的不适当药物。结论：在这项研究中，虽然我们不能寻找ADEs风险较高的口服药物，但我们能够寻找可能加剧老年患者ADEs预后的口服药物。这一结果有助于老年患者合理用药。
Objective: Elderly patients commonly experience adverse drug events (ADEs) owing to their poor drug metabolizing and excretion ability, and these often cause multiple organ dysfunction syndrome. Therefore, it is important that we identify the adverse drug events early on during prognosis. We searched for oral medicines that might exacerbate the prognosis of ADEs in elderly patients.< br> Methods: The objects under analysis were oral medicines that were registered in the Japanese Adverse Drug Event Report database (JADER). The associations between the elderly/non-elderly patients and exacerbation risk/non-exacerbation risk were analyzed by risk ratios (RR). The signal detection of exacerbation risk was defined as 95% confidence interval of lower limit of risk ratio> 1 and χ 2≥ 4.< br> Results: The oral medicines that might markedly exacerbate the prognosis of ADEs in the elderly patients in comparison with the ADEs of young patients included 84 items, of which 63 have not been described as potentially inappropriate medicines in all guidelines for medical treatment of the elderly patients.< br> Conclusion: In this study, while we could not search for oral medicines having a high risk of ADEs, we were able to search for oral medicines that might exacerbate the prognosis of ADEs in elderly patients. This result could contribute to the proper use of medicines in the elderly patients.