Navigation-associated medial parietal neurons in monkeys
Navigation-associated medial parietal neurons in monkeys
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DOI：
10.1073/pnas.0604277103
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发表时间：
2006-11
期刊：
影响因子：
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通讯作者：
Nobuya Sato;H. Sakata;Yuji Tanaka;M. Taira
中科院分区：
文献类型：
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作者：
Nobuya Sato;H. Sakata;Yuji Tanaka;M. Taira
为了研究人们到达目的地的路径知识的神经基础，我们记录了猴子在虚拟环境中主动导航时，猴子内侧顶叶区（MPR） 580个神经元的活动。其中180个神经元（31%）对猴子在虚拟环境中的动作表现出明显的反应。在这些反应神经元中，77%（139/180）表现出与特定位置的特定运动相关的反应（导航神经元），8%（14/180）表现出与特定运动相关的反应（运动选择性神经元），其余27个神经元（15%）是非选择性的。我们发现导航神经元在同一位置对同一运动的反应会根据猴子当前所走的路线进行调节，即以路线选择的方式进行调节（139个导航神经元中59个被测试的神经元中有32个是路线选择导航神经元）。muscimol对MPR神经元的可逆失活导致猴子在导航任务试验中迷路。这些结果表明，MPR通过整合位置信息和自身运动信息，在基于路线的导航中起着关键作用。
To examine the neural basis of route knowledge by which one can reach one's destination, we recorded the activity of 580 neurons in the monkey medial parietal region (MPR) while monkeys actively navigated through a virtual environment. One hundred eighty of these neurons (31%) showed significant responses to the monkeys' movements in the virtual environment. Of these responsive neurons, 77% (139/180) showed responses associated with a specific movement at a specific location (navigation neurons), 8% (14/180) showed responses associated with a specific movement (movement-selective neurons), and the remaining 27 neurons (15%) were nonselective. We found navigation neurons whose responses to the same movement at the same location were modulated depending on the route that the monkey was currently taking, that is, in a route-selective manner (32 of 59 tested neurons among 139 navigation neurons, route-selective navigation neurons). The reversible inactivation of MPR neurons by muscimol resulted in a monkey becoming lost during the navigation task trial. These results suggest that MPR plays a critical role in route-based navigation by integrating location information and self-movement information.