Non-mammalian vertebrate models and the endocannabinoid system: Relationships with gonadotropin-releasing hormone
Non-mammalian vertebrate models and the endocannabinoid system: Relationships with gonadotropin-releasing hormone
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DOI：
10.1016/j.mce.2008.01.009
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发表时间：
2008-04-16
影响因子：
4.1
通讯作者：
Meccariello, Rosaria
中科院分区：
文献类型：
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作者：
Chianese, Rosanna;Cobellis, Gilda;Meccariello, Rosaria
内源性大麻素通过大麻素受体(CB1和CB2)影响地方和中央两级的生殖功能。由于内源性大麻素系统的高度复杂性，以及神经系统外的广泛分布和高度进化保守性，深入的CB1分子特征可能有助于在多个水平上阐明内源性大麻素的活性。在这篇综述中，我们报道了CB1在非哺乳动物动物模型中的特征，特别是在无尾两栖动物青蛙中的特征；我们还描述了它在一年一度的性周期中的表达。此外，由于生殖功能受促性腺激素释放激素(GnRH)的控制，CB1在前脑的mRNA和蛋白表达谱与GnRH-I进行了比较，GnRH-I是一种主要参与促性腺激素释放的哺乳动物形式。(C)2008爱思唯尔爱尔兰有限公司。保留所有权利。
Endocannabinoids, via cannabinoid receptors (CB1 and CB2), affect reproductive functions at both local and central level. Due to the high complexity of the endocannabinoid system, to the widespread distribution outside the nervous system and to the high degree of evolutionary conservation, a deep CB1 molecular characterization among species may be useful to elucidate the activity of endocannabinoids at multiple levels. In this review we report CB1 characterization in non-mammalian animal models and, in particular, in the anuran amphibian, the frog, Rana esculenta; we also describe its expression during the annual sexual cycle. Moreover, since reproductive functions are under control of gonadotropin releasing hormone (GnRH), cb1 mRNA and protein expression profile in the forebrain has been compared to those of GnRH-I, the mammalian form primarily involved in gonadotropin release. (C) 2008 Elsevier Ireland Ltd. All rights reserved.