ROLE OF SEPTUM AND PREOPTIC AREA IN REGULATING MASCULINE AND FEMININE SEXUAL-BEHAVIOR IN MALE-RATS
ROLE OF SEPTUM AND PREOPTIC AREA IN REGULATING MASCULINE AND FEMININE SEXUAL-BEHAVIOR IN MALE-RATS
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DOI：
10.1016/0018-506x(90)90019-t
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发表时间：
1990-09-01
影响因子：
3.5
通讯作者：
ARAI, Y
中科院分区：
文献类型：
--
作者：
KONDO, Y;SHINODA, A;ARAI, Y
在去势的成年雄性大鼠中，研究了间隔或视前病变对雄性和雌性性行为的影响。脑外科手术后3周，动物植入含有睾酮（T）的硅橡胶管，每5天观察4次雄性性行为。在阳性行为试验结束后立即取出T管。两周后，动物植入含有雌二醇-17 β的硅橡胶管。(E2)每隔5天进行3次女性性行为测试。双侧外侧隔病变（LSL）和内侧视前病变（MPOL）有效地抑制了坐骑，插入和射精的性能，而内侧隔病变（MSL），背外侧视前病变（DPOL）和假手术没有显示出任何显着的抑制这些行为。在雌性性行为测试中，完整和假手术对照组雄性动物仅表现出较低的脊柱前凸活动。然而，LSL或DPOL显著促进了脊柱前凸反射的表现，而MSL和MPOL雄性动物的脊柱前凸活动与对照雄性动物无显著差异。这些结果表明，外侧隔不仅对雄性大鼠的雄性性行为有促进作用，而且对雌性性行为也有抑制作用。另一方面，内侧视前区可能在调节雄性大鼠的雄性性行为中起关键作用。
The effects of septal or preoptic lesions on both masculine and feminine sexual behaviors were examined in castrated adult male rats. Three weeks after brain surgery, animals were implanted with Silastic tubes containing testosterone (T) and observations of masculine sexual behavior were carried out four times every 5 days. T tubes were removed immmediately after the end of the masculine behavioral tests. Two weeks later, animals implanted with Silastic tubes containing estradiol-17.beta.(E2) were subjected to three feminine sexual behavioral tests at 5-day intervals. The bilateral lateral septal lesion (LSL) and the medial preoptic lesions (MPOL) effectively suppressed the performance of mounts, intromissions, and ejaculations, whereas the medial septal lesion (MSL), the dorsolateral preoptic lesion (DPOL), and the sham operation did not show any significant suppression of these behaviors. In the feminine sexual behavioral tests, intact and sham-operated control males showed only a low lordotic activity. However, the performance of the lordosis reflex was markedly facilitated by LSL or DPOL, while the lordotic activity of MSL and MPOL males was not significantly different from that of control males. These results suggest that the lateral septum exerts not only a facilitatory influence on masculine sexual behavior but also an inhibitory influence on feminine sexual behavior in male rats. On the other hand, the medial preoptic area may play a critical role in regulating masculine sexual behavior in male rats.