The effects of calcitonin on central neurons in the rat
The effects of calcitonin on central neurons in the rat
复制标题
降钙素对大鼠中枢神经元的影响
DOI：
10.1016/0304-3940(85)90601-9
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发表时间：
1985
影响因子：
2.5
通讯作者：
W. Schaffner
中科院分区：
文献类型：
--
作者：
U. Gerber;D. Felix;M. Felder;W. Schaffner
在麻醉大鼠中研究了鲑鱼降钙素对中枢神经元的影响。降钙素以离子电渗疗法持续抑制一半下丘脑前核和底丘脑神经元的自发活动，但对皮质和丘脑神经元几乎没有影响。降钙素还抑制测试神经元中谷氨酸诱发的活性。将降钙素注射到脑室系统中会导致大多数测试细胞中下丘脑细胞的自发放电显着减少。这种反应在使用降钙素后 20 至 30 分钟内开始出现。
The effects of salmon calcitonin on central neurons were studied in anesthetized rats. Calcitonin applied iontophoretically consistently inhibited spontaneous activity in half of the neurons tested in the anterior hypothalamic nucleus and subthalamus but had virtually no effect on cortical and thalamic neurons. Calcitonin also inhibited glutamate-evoked activity in the neurons tested. Calcitonin administered into the brain ventricular system led to a marked decrease in spontaneous discharge of hypothalamic cells in the majority of cells tested. The onset of this response began within 20 and 30 min of calcitonin application.