Naturally occurring anthraquinones: chemistry and therapeutic potential in autoimmune diabetes.
Naturally occurring anthraquinones: chemistry and therapeutic potential in autoimmune diabetes.
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DOI：
10.1155/2015/357357
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Yang WC
中科院分区：
文献类型：
--
作者：
Chien SC;Wu YC;Chen ZW;Yang WC
蒽醌是一类具有9，10-二氧代蒽核的芳香族化合物。迄今为止，已鉴定出79种天然存在的蒽醌类化合物，包括大黄素、大黄素甲醚、酪蛋白、连环素和大黄酸。大量文献表明，天然存在的蒽醌类化合物具有广泛的生物活性，如泻药、抗癌、抗炎、抗菌、利尿、血管舒张和植物雌激素活性，提示其在许多疾病中可能的临床应用。尽管近年来在理解蒽醌的化学和生物学方面取得了进展，但对其在自身免疫性疾病中的作用机制和治疗潜力的研究仍处于早期阶段。在本文中，我们简要介绍了自身免疫性糖尿病的病因，一种自身免疫性疾病，影响多达1000万世界各地，和趋化性在自身免疫性糖尿病中的作用。然后，我们概述了天然存在的蒽醌及其衍生物的化学结构和生物学特性，重点是最近的研究结果，他们的免疫调节。我们讨论了结构和活性的关系，作用方式，和治疗潜力的蒽醌类药物在自身免疫性糖尿病，包括一个新的战略，使用的蒽醌类药物在自身免疫性糖尿病。
Anthraquinones are a class of aromatic compounds with a 9,10-dioxoanthracene core. So far, 79 naturally occurring anthraquinones have been identified which include emodin, physcion, cascarin, catenarin, and rhein. A large body of literature has demonstrated that the naturally occurring anthraquinones possess a broad spectrum of bioactivities, such as cathartic, anticancer, anti-inflammatory, antimicrobial, diuretic, vasorelaxing, and phytoestrogen activities, suggesting their possible clinical application in many diseases. Despite the advances that have been made in understanding the chemistry and biology of the anthraquinones in recent years, research into their mechanisms of action and therapeutic potential in autoimmune disorders is still at an early stage. In this paper, we briefly introduce the etiology of autoimmune diabetes, an autoimmune disorder that affects as many as 10 million worldwide, and the role of chemotaxis in autoimmune diabetes. We then outline the chemical structure and biological properties of the naturally occurring anthraquinones and their derivatives with an emphasis on recent findings about their immune regulation. We discuss the structure and activity relationship, mode of action, and therapeutic potential of the anthraquinones in autoimmune diabetes, including a new strategy for the use of the anthraquinones in autoimmune diabetes.
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