Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease
Echogenicity of the substantia nigra in relatives of patients with sporadic Parkinson's disease
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DOI：
10.1016/s1053-8119(02)00035-6
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发表时间：
2003-02-01
期刊：
影响因子：
5.7
通讯作者：
Becker, G
中科院分区：
文献类型：
--
作者：
Ruprecht-Dörfler, P;Berg, D;Becker, G
黑质（SN）超声回声增强是帕金森病（PD）的典型超声表现。超声信号强度与组织铁含量有关，铁含量越高回声增强。最近的研究结果表明，SN的高回声性是黑质纹状体变性的一个重要易感因素。在这项研究中，我们确定了PD患者一级亲属中帕金森病特征性超声征象的患病率。14例散发性PD患者及其58名亲属接受了神经学、神经心理学和超声检查。此外，对4对亲缘关系（每对亲缘关系中有一对表现为SN回声增强，另一对表现为SN回声正常）进行了18f - dopa PET检查。经颅超声检查，58例亲属中有26例表现出SN高回声。24名亲属表现出轻微的运动迟缓迹象。具有SN高回声型的亲属比没有这种回声型的亲属更容易出现运动障碍（16 vs 8个亲属，U检验，P = 0.01）和执行功能受损（伦敦塔任务，最少移动次数解决问题，U检验，P = 0.012）。此外，与没有这种超声征的亲属相比，SN高回声性受试者的壳核f -18-多巴摄取（内流常数）降低（Wilcoxon, P = 0.03）。总之，大约45%的PD患者亲属表现出SN回声增强。该征象与临床表现和客观测量相关联，表明黑质纹状体功能在一定程度上受损。(C) 2003 Elsevier Science（美国）版权所有。
Increased echogenicity of the substantia nigra (SN) on ultrasound is a typical sonograpbic finding in Parkinson's disease (PD). Sonographic signal intensity of the SN is related to tissue iron content with higher iron level being associated with increased echogenicity. Recent findings indicate that hyperechogenicity of the SN represents an important susceptibility factor for nigrostriatal degeneration. In this study we determined the prevalence of a characteristic ultrasound sign of Parkinson's disease in first-degree relatives of PD patients. Fourteen patients with sporadic PD and 58 of their relatives underwent neurological, neuropsychological, and ultrasound examination. In addition, four pairs of relatives (one member of each pair exhibiting increased echogenicity of the SN and the other with regular SN echogenicity) underwent 18 F-Dopa PET examination. On transcranial sonography, 26 of the 58 relatives exhibited SN hyperechogenicity. Twenty-four relatives showed minor signs of motor slowing. Relatives with SN hyperechogenicity more often showed signs of hypokinesia (16 v 8 relatives; U test, P = 0.01) and impaired executive functions (Tower of London task, problems solved with the minimum number of moves; U test, P = 0.012) than relatives without this echo pattern. In addition, F-18-Dopa uptake (influx constants) at the putamen was reduced in subjects with SN hyperechogenicity compared to their relatives without this ultrasound sign (Wilcoxon, P = 0.03). In conclusion, approximately 45% of relatives of PD patients exhibited an increased echogenicity of the SN. This sign is associated with clinical findings and objective measurements, indicating some degree of impaired nigrostriatal function. (C) 2003 Elsevier Science (USA). All rights reserved.