Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells
Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells
复制标题
胃癌来源的外泌体通过靶向内皮细胞中的 miR-29a/VEGF 轴介导 circRNA 的递送以促进血管生成。
DOI：
10.1016/j.bbrc.2021.04.099
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发表时间：
2021-05-06
影响因子：
3.1
通讯作者：
Ba, Yi
中科院分区：
文献类型：
--
作者：
Li, Shuang;Li, Jialu;Ba, Yi
越来越多的证据发现，环状RNA（circRNA）通过调节细胞质中的基因表达，在各种疾病的发生和发展中发挥着关键作用。然而，circ_0044366（称为 circ29）在胃癌（GC）中的作用尚不清楚。我们检测到外泌体circ29被证实在GC中高表达，并且可以通过外泌体通讯显着损害HUVEC的增殖、迁移、管形成。有趣的是，这种效应可以被 miR-29a 的效应阻断。总之，我们证实circ29作为miR-29a的海绵，通过调节VEGF通路在GC的发生和发展中发挥重要作用。因此，它可能作为GC治疗的潜在靶点。
Accumulating evidence has been found that circular RNA (circRNA) plays a critical role in the initiation and development of various diseases by modulating gene expression in the cytoplasm. However, the role of circ_0044366 (termed circ29) in gastric cancer (GC) has yet to be elusive. We detected that exosomal circ29 was confirmed to be highly expressed in GC and can significantly impair the proliferation, migration, tube formation of HUVEC by exosomal communication. Interestingly, this effect could be blocked by the effect of miR-29a. In brief, we confirmed that circ29, as a sponge of miR-29a, plays a responsible role in the occurrence and development of GC by regulating the VEGF pathway. Therefore, it may be used as a potential target for the treatment of GC.