Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice
Mouse pancreatic polypeptide modulates food intake, while not influencing anxiety in mice
复制标题
DOI：
10.1016/s0196-9781(99)00155-2
复制
发表时间：
1999-12-01
期刊：
影响因子：
3
通讯作者：
Kasuga, M
中科院分区：
文献类型：
--
作者：
Asakawa, A;Inui, A;Kasuga, M
本研究旨在研究人工合成的小鼠胰多肽(MPP)对小鼠摄食和焦虑的影响。脑室注射MPP(0.003-3nmol)可剂量依赖性地增加摄食量。侧脑室注射MPP(0.03-30nmol)后20min开始显著升高，持续4h，并呈剂量依赖性减少摄食量。在高架迷宫实验中，侧脑室注射MPP(0.003-3nmol)对焦虑行为无明显影响。这些结果表明，MPP调节食物摄入量，大脑中的Y4受体可能有助于调节摄食，而似乎不影响小鼠的焦虑。(C)1999 Elsevier Science Inc.保留所有权利。
This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (ICV) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after ICV injection and continued for 4 h, The intraperitoneal (IP) injection of mPP (0.03-30 nmol) dose-dependently decreased food intake. A significant decreases was observed 20 min after IP injection and continued for 4 h, In the elevated plus maze test, the ICV injection of mPP (0.003-3 nmol) did not affect anxiety behavior. These results suggest that mPP modulates food intake and the Y4 receptor in the brain may contribute to the regulation of feeding, whereas appearing not to influence anxiety in mice. (C) 1999 Elsevier Science Inc. All rights reserved.