Effect of corticosterone on the prolactin response to psychological and physical stress in rats.
Effect of corticosterone on the prolactin response to psychological and physical stress in rats.
复制标题
皮质酮对大鼠催乳素对心理和身体应激反应的影响。
DOI：
10.1016/0024-3205(84)90183-8
复制
发表时间：
1984
期刊：
影响因子：
6.1
通讯作者：
A. Ratner
中科院分区：
文献类型：
--
作者：
D. Yelvington;G. Weiss;A. Ratner
皮质酮和催乳素 (PRL) 水平都会因压力而增加。在这些研究中，我们研究了皮质酮对 PRL 对身体（足部电击）和心理（新环境）压力的反应的影响。使用三组大鼠：假肾上腺切除术（SHAM）、肾上腺切除术（ADX）和皮质酮替代疗法（ADX+CORT）。皮质酮治疗的动物接受80微克皮质酮/毫升的饮用水。通过留置插管抽取血样，并使用放射免疫测定法测定 PRL 值。与 ADX+CORT 大鼠相比，ADX 大鼠在被放置在水上平台（新环境）或接受间歇性足部电击时表现出始终较高的 PRL 反应。后一组的 PRL 反应与 SHAM 动物相似。这些发现表明，动物的皮质酮水平可以显着减弱 PRL 对身体和心理压力的反应程度。这些发现进一步强调，PRL 对应激的反应不仅取决于应激源的立即行动，还取决于动物之前的应激历史。
Both corticosterone and prolactin (PRL) levels increase in response to stress. In these studies we examined the effect of corticosterone on the PRL response to both physical (footshock) and psychological (novel environment) stress. Three groups of rats were used: sham adrenalectomized (SHAM), adrenalectomized (ADX), and adrenalectomized with corticosterone replacement (ADX+CORT). The corticosterone-treated animals received 80 ug corticosterone/ml drinking water. Blood samples were drawn via an indwelling cannula and PRL values determined using radioimmunoassay. ADX rats showed a consistently greater PRL response to being placed on a platform above water (novel environment) or when receiving intermittant footshock than did ADX+CORT rats. The PRL response of the latter group was similar to that of the SHAM animals. These findings indicate that corticosterone levels of an animal can significantly attenuate the magnitude of the PRL response to both physical and psychological stress. These findings further emphasize that the PRL response to stress is dependent not only upon the immediate action of the stressor, but also the prior stress history of the animal.