BRAIN SENSORIMOTOR SYSTEM ATROPHY DURING THE EARLY STAGE OF SPINAL CORD INJURY IN HUMANS
BRAIN SENSORIMOTOR SYSTEM ATROPHY DURING THE EARLY STAGE OF SPINAL CORD INJURY IN HUMANS
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人类脊髓损伤早期的大脑感觉运动系统萎缩
DOI：
10.1016/j.neuroscience.2014.02.013
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发表时间：
2014-04-25
期刊：
影响因子：
3.3
通讯作者：
Sun, T. -S.
中科院分区：
文献类型：
--
作者：
Hou, J. -M.;Yan, R. -B.;Sun, T. -S.
脊髓损伤（SCI）通常会导致严重的感觉和运动缺陷低于脊髓病变。先前的动物模型已经显示SCI后神经感觉运动系统的显著萎缩变化。然而，SCI后人脑的具体解剖学变化仍然知之甚少。本研究的目的是探讨脊髓损伤早期脊髓结构的变化，并进一步探讨脊髓结构变化与脊髓损伤患者感觉运动功能之间的关系。研究参与者包括20名SCI患者和30名匹配的健康对照者。SCI后的平均时间为8.9 ± 2.7周（范围4-12周）。采用基于体素的形态学测量方法研究灰质和白色物质体积变化的区域。与健康对照组相比，SCI患者在初级运动皮层（M1）、初级躯体感觉皮层（S1）、辅助运动区（SMA）和丘脑中表现出明显的灰质萎缩，在双侧大脑脚水平的皮质脊髓束中也表现出白色萎缩。此外，SCI患者初级运动皮质的灰质体积与美国脊髓损伤协会运动总评分呈正相关。总之，我们的研究结果表明，脊髓损伤引起人类感觉运动系统的显着解剖学变化，这些解剖学变化可能发生在脊髓损伤的早期阶段。未来旨在恢复SCI后感觉运动功能的治疗需要关注大脑中的这些解剖学变化。(C)2014年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Spinal cord injury (SCI) usually leads to severe sensory and motor deficits below the spinal lesion. Previous animal models have shown significant atrophic changes in the neural sensorimotor system following SCI. However, specific anatomical changes in the human brain following SCI remain poorly understood. The purpose of the present study was to investigate structural changes during the early stage of SCI, and to investigate further the association between the structural changes and patients' sensorimotor functions. The study participants included 20 patients with SCI and 30 matched healthy controls. The mean period post-SCI was 8.9 +/- 2.7 weeks (range 4-12 weeks). Voxelbased morphometry was used to investigate the regions with gray and white matter volume changes. Compared to healthy controls, patients with SCI showed significant gray matter atrophy in the primary motor cortex (M1), primary somatosensory cortex (S1), supplementary motor area (SMA), and thalamus, as well as white matter atrophy in the corticospinal tracts at the level of the bilateral cerebral peduncles. In addition, gray matter volume in the primary motor cortex was positively correlated with the total American Spinal Injury Association motor score in patients with SCI. In conclusion, our findings suggest that SCI causes significant anatomical changes in the human sensorimotor system, and that these anatomical changes may occur in the early phase of SCI. Future treatments that aim to restore sensorimotor functions following SCI need to attend to these anatomical changes in the brain. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.