Structural development of benzhydrol-type 1′-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis
Structural development of benzhydrol-type 1′-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis
复制标题
DOI：
10.1248/cpb.56.1490
复制
发表时间：
2008-10-01
影响因子：
1.7
通讯作者：
Hashimoto, Yuichi
中科院分区：
文献类型：
--
作者：
Misawa, Takashi;Aoyama, Hiroshi;Hashimoto, Yuichi
基于定量构效关系 (QSAR) 分析，开发了 1'-乙酰氧基胡椒酚乙酸酯 (ACA) 的苯甲醇型类似物作为人类白血病 HL-60 细胞生长的抑制剂。含有蒽基部分的类似物(C)是一种有效的抑制剂，IC50值为0.12μm。
Benzhydrol-type analogs of 1'-acetoxychavicol acetate (ACA) were developed as inhibitors of human leukemia HL-60 cell growth based on quantitative structure-activity relationship (QSAR) analysis. An analog containing an anthracenyl moiety (C) was a potent inhibitor with the IC50 value of 0.12 mu m.