Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.
Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.
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针灸治疗缺血性中风的机制：传导与调节
DOI：
10.4103/1673-5374.297061
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发表时间：
2021-05
影响因子：
6.1
通讯作者：
Lai PH
中科院分区：
文献类型：
--
作者：
Cao BQ;Tan F;Zhan J;Lai PH
脑缺血/再灌注后的炎症反应是神经损伤和修复的重要原因。脑缺血/再灌注后，小胶质细胞被激活，大量循环炎症细胞浸润患处。这导致炎症介质的分泌和炎症级联反应，最终导致继发性脑损伤，包括神经元坏死、血脑屏障破坏、脑水肿和氧化应激反应。炎症信号通路的激活在缺血性脑卒中的病理过程中发挥着关键作用。越来越多的证据表明，针灸可以减轻脑缺血/再灌注后的炎症反应，促进受损神经系统的修复。针灸不仅可以抑制炎症细胞的活化和浸润，还可以调节炎症相关细胞因子的表达，平衡促炎和抗炎因子的作用，干扰炎症信号通路。因此，研究针刺治疗脑缺血/再灌注损伤后炎症信号通路的传递和调节机制，为临床针刺治疗此类损伤提供理论依据。我们综述了脑缺血/再灌注后炎症细胞、介质和通路的整体状况，并讨论了针灸对炎症信号通路网络可能的协同干预，为探讨针灸促进神经功能恢复的多种分子机制提供基础。
The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair. After cerebral ischemia/reperfusion, microglia are activated, and a large number of circulating inflammatory cells infiltrate the affected area. This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage, including neuron necrosis, blood-brain barrier destruction, cerebral edema, and an oxidative stress response. Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke. Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system. Acupuncture can not only inhibit the activation and infiltration of inflammatory cells, but can also regulate the expression of inflammation-related cytokines, balance the effects of pro-inflammatory and anti-inflammatory factors, and interfere with inflammatory signaling pathways. Therefore, it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture. Our review summarizes the overall conditions of inflammatory cells, mediators, and pathways after cerebral ischemia/reperfusion, and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration.
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影响因子：
--
作者：
Cheng CY;Lin JG;Tang NY;Kao ST;Hsieh CL
通讯作者：
Hsieh CL
影响因子：
3.6
作者：
Arumugam, Thiruma V.;Cheng, Yi-Lin;Jo, Dong-Gyu
通讯作者：
Jo, Dong-Gyu
影响因子：
9.3
作者：
Cherry JD;Olschowka JA;O'Banion MK
通讯作者：
O'Banion MK
DOI：
10.1073/pnas.96.22.12866
发表时间：
1999-10-26
影响因子：
11.1
作者：
Alessandrini, A;Namura, S;Bonventre, JV
通讯作者：
Bonventre, JV
影响因子：
2.9
作者：
Choudhury, Gourav Roy;Ryou, Myoung-Gwi;Poteet, Ethan;Wen, Yi;He, Runlian;Sun, Fen;Yuan, Fang;Jin, Kunlin;Yang, Shao-Hua
通讯作者：
Yang, Shao-Hua