Fibrin D-dimer and cardiovascular risk.
Fibrin D-dimer and cardiovascular risk.
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DOI：
10.1055/s-2005-922485
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发表时间：
2005-11-01
期刊：
影响因子：
--
通讯作者：
Lowe, Gordon D O
中科院分区：
文献类型：
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作者：
Lowe, Gordon D O
纤维蛋白D-二聚体是检测凝血激活和体内循环血液中纤维蛋白形成和溶解的最常用临床检测方法，在过去15年发表的研究中与心血管疾病风险相关。这篇综述依次讨论了分析和分析前的考虑;与危险因素的关系;与冠心病、房颤、中风和脑血管疾病、外周动脉疾病和静脉血栓栓塞的关系。这些相关性表明，活化凝血和体内纤维蛋白形成和溶解可能在动脉、心内和静脉血栓栓塞中发挥作用。D-二聚体在预测心血管风险、提示患者预防性抗凝治疗和监测抗凝治疗方面的潜在临床应用需要进一步研究。来自不同测定的结果的协调将增加临床实用性。
Fibrin D-dimer, the most commonly used clinical assay for detection of coagulation activation and in vivo fibrin formation and lysis in circulating blood, has been associated with risks of cardiovascular diseases in studies published over the past 15 years. This review discusses, in turn, analytic and preanalytic considerations; associations with risk factors; and associations with coronary heart disease, atrial fibrillation, stroke and cerebrovascular disease, peripheral arterial disease, and venous thromboembolism. These associations suggest that activated coagulation and in vivo fibrin formation and lysis may play a role in arterial, intracardiac, and venous thromboembolism. The potential clinical utility of D-dimer in prediction of cardiovascular risk, in indicating patient groups for prophylactic anticoagulation and in monitoring of anticoagulation, requires further study. Harmonization of results from different assays would increase clinical utility.