Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase
Alpha-Naphthoflavone: An Inhibitor of Hydrocarbon Cytotoxicity and Microsomal Hydroxylase
复制标题
α-萘黄酮：碳氢化合物细胞毒性和微粒体羟化酶的抑制剂
作者：
L. Diamond;H. Gelboin
α-萘黄酮抑制仓鼠胚胎细胞培养物中 3,4-苯并芘和 7,12-二甲基苯并(a)蒽的代谢，并保护细胞免受这些致癌物质对细胞增殖的抑制。 α-萘黄酮还抑制诱导仓鼠胚胎细胞匀浆和先前用多环芳烃处理的大鼠的肝微粒体中的芳基烃羟化酶活性，但不抑制对照大鼠的微粒体中的芳基烃羟化酶活性。
Alpha-naphthoflavone inhibits the metabolism of 3,4-benzopyrene and 7,12-dimethylbenz(a)anthracene in hamster enlbryo cell cultures and protects the cells against the inhibition of cell multiplication by these carcinogens. Alphla-nalphthoflavone also inhibits the aryl hydrocarbon hydroxylase activity in homogenates of induced hamster embryo cells and in liver microsomes from rats previously treated with polycyclic aromatic hydrocarbons, but not in microsomes from control rats.