Targeting platelet-derived growth factor as a therapeutic approach in pulmonary fibrosis.
Targeting platelet-derived growth factor as a therapeutic approach in pulmonary fibrosis.
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DOI：
10.2152/jmi.60.175
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Y. Nishioka;M. Azuma;M. Kishi;Y. Aono
中科院分区：
文献类型：
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作者：
Y. Nishioka;M. Azuma;M. Kishi;Y. Aono
特发性肺纤维化（IPF）是一种进行性致死性肺部疾病，以成纤维细胞增殖和细胞外基质沉积为特征。由于IPF的预后仍然很差，因此迫切需要新的治疗方式。因此，寻找治疗IPF的分子靶点具有重要意义。最近对IPF发病机制的了解表明肺泡上皮II型细胞（AECII）和成纤维细胞的关键作用。尽管IPF中涉及的详细机制仍不清楚，但认为由受损的AECII产生的各种促纤维化介质通过刺激成纤维细胞在肺纤维化的进展中发挥作用。其中，血小板源性生长因子（platelet-derived growth factor，PDGF）通过刺激成纤维细胞的增殖和迁移而成为重要的生长因子之一。在这篇综述中，我们讨论了PDGF在肺纤维化中的作用以及作为IPF治疗靶点的可能性。
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease characterized by the proliferation of fibroblasts and deposition of extracellular matrix. Since the prognosis of IPF is still poor, novel therapeutic modalities are strongly required. For this reason, to find molecular target for therapy of IPF is of much importance. The recent understanding of pathogenesis in IPF indicates the critical role of alveolar epithelial type II cells (AECII) and fibroblasts. Although the detailed mechanisms involved in IPF is still unclear, various profibrotic mediators which are produced by the injured AECII are thought to play a role in the progression of pulmonary fibrosis via stimulating fibroblasts. Among them, platelet-derived growth factor (PDGF) is one of critical growth factors by stimulating the proliferation and migration of fibroblasts. In this review, we discuss the role of PDGF in pulmonary fibrosis and the possibility as a therapeutic target for IPF.