Protein Kinase A
Protein Kinase A
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DOI：
10.32388/saugdn
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发表时间：
2020-02
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cAMP的大多数细胞效应通过PKA通过靶蛋白的丝氨酸或苏氨酸磷酸化介导。人蛋白激酶A（cAMP Ser/T hr蛋白激酶家族）是一种无活性的四聚体胞质全酶，由同源或异源二聚体调节亚基和两个催化亚基组成。cAMP导致失活全酶解离成cAMP结合的调节亚基二聚体和两个游离的单体催化亚基，其磷酸化许多细胞质和细胞核底物。在人类中，已经鉴定了调节性PRKAR 1A、PRKAR 1B、PRKAR 2A和PRKAR 2B亚基以及催化性PRKACA、PRKACB和PRKACG亚基。(NCI)Qeios ·定义，2020年2月2日
Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/T hr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homoor heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified. (NCI) Qeios · Definition, February 2, 2020