Influence of intravenous contrast medium on dose calculation using CT in treatment planning for oesophageal cancer.
Influence of intravenous contrast medium on dose calculation using CT in treatment planning for oesophageal cancer.
复制标题
食管癌治疗计划中静脉注射造影剂对 CT 剂量计算的影响。
DOI：
10.7314/apjcp.2013.14.3.1609
复制
发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Yong Yin
中科院分区：
文献类型：
--
作者：
Hong;Jinhu Chen;Wei Zhang;D. Shang;Baosheng Li;T. Sun;Xiu;Yong Yin
目标
评估静脉造影剂对食管癌放射治疗计划中剂量计算的影响。
方法
共有 22 名食管癌患者进行了静脉内造影。胸部大血管和心脏中增强血流的亨斯菲尔德单位 (HU) 值被 45 HU 覆盖以模拟非对比增强 CT 图像，并覆盖 145 HU、245 HU、345 HU 和 445 HU 以模拟不同的对比增强场景。 1000 HU 和-1000 HU 用于评估两种非生理极端场景。计算不同场景的剂量分布变化来量化对比度增强的效果。
结果
在对比增强场景中，计划目标体积 (PTV) 的剂量平均变化小于 1.0%，整个肺和脊髓的剂量变化小于 0.5%。当血流的 HU 值超过 245 时，心脏 V40 的平均变化超过 1.0%。在非生理极端情况下，PTV的剂量变化小于1.0%，而危及器官的剂量计算大于2.0%。
结论
造影剂的使用不会显着影响PTV、肺和脊髓的剂量计算。然而，它确实对心脏的剂量准确性有影响。
OBJECTIVE
To evaluate the effect of intravenous contrast on dose calculation in radiation treatment planning for oesophageal cancer.
METHODS
A total of 22 intravein-contrasted patients with oesophageal cancer were included. The Hounsfield unit (HU) value of the enhanced blood stream in thoracic great vessels and heart was overridden with 45 HU to simulate the non-contrast CT image, and 145 HU, 245 HU, 345 HU, and 445 HU to model the different contrast-enhanced scenarios. 1000 HU and -1000 HU were used to evaluate two non-physiologic extreme scenarios. Variation in dose distribution of the different scenarios was calculated to quantify the effect of contrast enhancement.
RESULTS
In the contrast-enhanced scenarios, the mean variation in dose for planning target volume (PTV) was less than 1.0%, and those for the total lung and spinal cord were less than 0.5%. When the HU value of the blood stream exceeded 245 the average variation exceeded 1.0% for the heart V40. In the non-physiologic extreme scenarios, the dose variationof PTV was less than 1.0%, while the dose calculations of the organs at risk were greater than 2.0%.
CONCLUSIONS
The use of contrast agent does not significantly influence dose calculation of PTV, lung and spinal cord. However, it does have influence on dose accuracy for heart.