Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism.
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism.
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短链脂肪酸及其与炎症、糖和脂代谢信号通路的关系。
DOI：
10.3390/ijms21176356
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发表时间：
2020-09-02
影响因子：
5.6
通讯作者：
Zhu L
中科院分区：
文献类型：
--
作者：
He J;Zhang P;Shen L;Niu L;Tan Y;Chen L;Zhao Y;Bai L;Hao X;Li X;Zhang S;Zhu L
短链脂肪酸（SCFAs）主要由肠道微生物厌氧发酵产生，尤其是乙酸、丙酸和丁酸。SCFAs在调节肠道能量代谢和能量供应、维持肠道环境稳态等方面发挥着重要作用。近年来，许多研究表明，短链脂肪酸具有生理上的有益作用，并发现了与短链脂肪酸产生、吸收、代谢和肠道作用相关的信号通路。关于SCFAs的两个主要信号通路，g蛋白偶联受体（GPRCs）和组蛋白去乙酰化酶（hdac），已经得到了很好的认识。本文就SCFAs的生物学特性及其在炎症和糖脂代谢中的信号通路的研究进展进行综述。
Short-chain fatty acids (SCFAs), particularly acetate, propionate and butyrate, are mainly produced by anaerobic fermentation of gut microbes. SCFAs play an important role in regulating energy metabolism and energy supply, as well as maintaining the homeostasis of the intestinal environment. In recent years, many studies have shown that SCFAs demonstrate physiologically beneficial effects, and the signalling pathways related to SCFA production, absorption, metabolism, and intestinal effects have been discovered. Two major signalling pathways concerning SCFAs, G-protein-coupled receptors (GPRCs) and histone deacetylases (HDACs), are well recognized. In this review, we summarize the recent advances concerning the biological properties of SCFAs and the signalling pathways in inflammation and glucose and lipid metabolism.