Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo
Evaluation of treatment response to autologous transplantation of noncultured melanocyte/keratinocyte cell suspension in patients with stable vitiligo
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DOI：
10.1590/abd1806-4841.20175700
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发表时间：
2017-06-01
影响因子：
1.7
通讯作者：
Ramos, Camila Gontijo
中科院分区：
文献类型：
--
作者：
Ramos, Mariana Gontijo;Ramos, Daniel Gontijo;Ramos, Camila Gontijo
BACKGROUND: Vitiligo is a chronic disease characterized by the appearance of achromic macules caused by melanocyte destruction. Surgical treatments with melanocyte transplantation can be used for stable vitiligo cases.OBJECTIVES: To evaluate treatment response to the autologous transplantation of noncultured epidermal cell suspension in patients with stable vitiligo.METHODS: Case series study in patients with stable vitiligo submitted to noncultured epidermal cell suspension transplantation and evaluated at least once, between 3 and 6 months after the procedure, to observe repigmentation and possible adverse effects. The maximum follow-up period for some patients was 24 months.RESULTS: Of the 20 patients who underwent 24 procedures, 25% showed an excellent rate of repigmentation, 50% good repigmentation, 15% regular, and 10% poor response. The best results were observed in face and neck lesions, while the worst in extremity lesions (88% and 33% of satisfactory responses, respectively). Patients with segmental vitiligo had a better response (84%) compared to non-segmental ones (63%). As side effects were observed hyperpigmentation of the treated area and the appearance of Koebner phenomenon in the donor area.STUDY LIMITATIONS: Some limitations of the study included the small number of patients, a subjective evaluation, and the lack of long-term follow-up on the results.CONCLUSION: Noncultured epidermal cell suspension transplantation is efficient and well tolerated for stable vitiligo treatment, especially for segmental vitiligo on the face and neck.
