Peripheral nervous system function and organophosphate pesticide use among licensed pesticide applicators in the Agricultural Health Study.
Peripheral nervous system function and organophosphate pesticide use among licensed pesticide applicators in the Agricultural Health Study.
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DOI：
10.1289/ehp.1103944
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发表时间：
2012-04
影响因子：
10.4
通讯作者：
Gerr F
中科院分区：
文献类型：
--
作者：
Starks SE;Hoppin JA;Kamel F;Lynch CF;Jones MP;Alavanja MC;Sandler DP;Gerr F
背景资料：人类长期暴露于有机磷农药（OP）而不中毒，与周围神经系统（PNS）功能不良有关的证据有限。目的：我们调查了OP农药的使用和PNS功能之间的关联管理PNS测试701男性农药施用者在农业健康研究（AHS）。研究方法：参与者完成了神经系统体格检查（NPx）和电生理测试以及手部力量，摇摆速度和振动触觉阈值的测试。关于16种有机磷农药终生使用情况的自我报告信息来自AHS访谈和研究问卷。农药的使用和PNS功能的措施之间的关联进行了估计与线性和逻辑回归控制的年龄和结果的具体协变量。结果如下：观察到16种OP农药中的10种与6种NPx结果中的一种或多种之间的关联的比值比（OR）显著增加。最值得注意的是，脚趾本体感觉异常显着与以往任何时候都使用6 OP农药，OR值范围从2.03至3.06;单调增加的关联强度与增加使用的6种农药中的3种。OP农药的使用和电生理测试，手的力量，摇摆速度，和振动触觉阈值之间观察到大多数零关联。结论：这项研究提供了一些证据表明，长期暴露于OP农药与农药施用者PNS功能受损的迹象有关。
Background: Evidence is limited that long-term human exposure to organophosphate (OP) pesticides, without poisoning, is associated with adverse peripheral nervous system (PNS) function. Objective: We investigated associations between OP pesticide use and PNS function by administering PNS tests to 701 male pesticide applicators in the Agricultural Health Study (AHS). Methods: Participants completed a neurological physical examination (NPx) and electrophysiological tests as well as tests of hand strength, sway speed, and vibrotactile threshold. Self-reported information on lifetime use of 16 OP pesticides was obtained from AHS interviews and a study questionnaire. Associations between pesticide use and measures of PNS function were estimated with linear and logistic regression controlling for age and outcome-specific covariates. Results: Significantly increased odds ratios (ORs) were observed for associations between ever use of 10 of the 16 OP pesticides and one or more of six NPx outcomes. Most notably, abnormal toe proprioception was significantly associated with ever use of 6 OP pesticides, with ORs ranging from 2.03 to 3.06; monotonic increases in strength of association with increasing use was observed for 3 of the 6 pesticides. Mostly null associations were observed between OP pesticide use and electrophysiological tests, hand strength, sway speed, and vibrotactile threshold. Conclusions: This study provides some evidence that long-term exposure to OP pesticides is associated with signs of impaired PNS function among pesticide applicators.