An index of the fractal characteristic of an airway tree is associated with airflow limitations and future body mass index reduction in COPD patients.
An index of the fractal characteristic of an airway tree is associated with airflow limitations and future body mass index reduction in COPD patients.
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气道树的分形特征指数与 COPD 患者的气流限制和未来体重指数降低相关。
DOI：
10.1152/japplphysiol.00461.2019
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发表时间：
2020
影响因子：
3.3
通讯作者：
Y. Nakano
中科院分区：
文献类型：
--
作者：
D. Kinose;E. Ogawa;S. Kawashima;Yumiko Matsuo;Ruriko Yukimura;A. Yamazaki;Saiko Yoshihashi;Yoko Hirayama;Y. Nakano
气道树和血管树的分形紊乱已在肺部疾病中进行了研究。在这里，我们成功地将 Mishima 的 D 应用到慢性阻塞性肺疾病 (COPD) 和非 COPD 吸烟者 (n = 162) 的多探测器计算机断层扫描 (MDCT) 图像中测量的支气管最小内横截面积 (iCSA)，方法是在以下公式中定义 D； logN(≥X) = - D * logX + c，其中X是某个iCSA值，N(≥X)是iCSA大于或等于X的气道分支的数量。从数学上讲，iCSA的D与分叉处iCSA的预期减少率相关，可以通过2-1/D来估计。 iCSA 的 D 还与气道代数中的盒计数分形维数和 Weibel 缩减率相关性较弱，这表明气道树不是完美的分形对象，并且分支分叉是不对称的。 iCSA 的 D 显示与研究参与者气流受限的肺功能测量呈正相关。此外，代表外围的 iCSA D 显示与未来体重指数降低相关，很可能作为赫斯-默里定律预测的呼吸能量效率的指标。 iCSA D 可能有助于了解阻塞性肺病的发病机制。
Disorders of the fractality of an airway tree and a vessel tree have been studied in pulmonary diseases. Here, we successfully applied Mishima's D to the bronchial minimal inner cross-sectional area (iCSA) measured in multi-detector computed tomography (MDCT) images of chronic obstructive pulmonary disease (COPD) and non-COPD smokers (n = 162), by defining D in the following formula; logN(≥X) = - D * logX + c, where X is a certain iCSA value, and N(≥X) is the number of airway branches having iCSA greater than or equal to X. Mathematically, this D of iCSA was associated with the expected reduction ratio of iCSA at bifurcations, which can be estimated by 2-1/D. This D of iCSA also correlated weakly with the box-counting fractal dimension and Weibel's reduction ratio over airway generations, which indicated that the airway tree was not a perfect fractal object and that the branch bifurcation was asymmetrical. The D of iCSA showed positive correlations with lung function measurements of airflow limitation in study participants. In addition, D of iCSA representing the periphery showed an association with future body mass index reduction, most likely as an indicator of energy efficacy for breathing as predicted by Hess-Murray's law. D of iCSA may be helpful to understand the pathogenesis of obstructive lung diseases.
DOI：
10.1016/j.clinbiomech.2017.11.005
发表时间：
2019-06
期刊：
Clinical biomechanics (Bristol, Avon)
影响因子：
--
作者：
Van de Moortele T;Goerke U;Wendt CH;Coletti F
通讯作者：
Coletti F
DOI：
10.1056/nejmoa1513737
发表时间：
2016-05-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
McGeachie MJ;Yates KP;Zhou X;Guo F;Sternberg AL;Van Natta ML;Wise RA;Szefler SJ;Sharma S;Kho AT;Cho MH;Croteau-Chonka DC;Castaldi PJ;Jain G;Sanyal A;Zhan Y;Lajoie BR;Dekker J;Stamatoyannopoulos J;Covar RA;Zeiger RS;Adkinson NF;Williams PV;Kelly HW;Grasemann H;Vonk JM;Koppelman GH;Postma DS;Raby BA;Houston I;Lu Q;Fuhlbrigge AL;Tantisira KG;Silverman EK;Tonascia J;Weiss ST;Strunk RC
通讯作者：
Strunk RC
通过体内计算机断层扫描和体外 MRI 研究人类传导气道的形态和功能特性。
DOI：
10.1152/japplphysiol.00490.2017
发表时间：
2018
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
VandeMoortele,Tristan;Wendt,ChristineH;Coletti,Filippo
通讯作者：
Coletti,Filippo