A geological analysis for the environmental cause of human birth defects based on GIS
A geological analysis for the environmental cause of human birth defects based on GIS
复制标题
基于GIS的人类出生缺陷环境成因地质分析
DOI：
10.1080/00222930600803282
复制
发表时间：
2006-01-01
影响因子：
1.8
通讯作者：
Zheng, Xiaoying
中科院分区：
文献类型：
--
作者：
Li, Xinhu;Wang, Jinfeng;Zheng, Xiaoying
以往关于环境因素对出生缺陷风险的研究主要集中在有毒物质暴露的剂量-反应关系上。本文旨在探讨地质背景与神经管缺陷（NTD）出生缺陷发生率的关系。采用贝叶斯方法调整NTD出生缺陷的发生率;采用参数和非参数统计方法量化地质背景与人类出生缺陷风险之间的相关性。在以太古界为核心层的背斜岩两翼，岩层年龄与出生缺陷发生风险呈显著正相关。在断裂带周围4km以内的区域，NTD出生缺陷发生率最高，随着缓冲距离的增加NTD出生缺陷发生率降低。在宏观空间尺度上，地质背景与出生缺陷风险具有显著相关性，居住在断裂带附近的人群具有较高的出生缺陷风险。
Previous studies on birth defects risk from environmental factors focused on the dose-response relationship of exposure to toxic materials. The purpose of this article is to investigate the relationship between the geological background and occurrence ratio of neural tube defect (NTD) birth defects. Bayesian method was used to adjust the occurrence of NTD birth defects; both parametric and nonparametric statistical methods were used to quantify the correlation between geological background and human birth defects risk. At the two limbs of anticline rock, whose kernel stratum is of Archean kingdom, age of rock strata showed significant positive correlation to the occurrence of birth defects risk. In the region inside 4 km around the fault zone, the occurrence ratio of NTD birth defects is the highest; and decreases when the buffer distance increases. In macro spatial scale, geological background has a significant correlation to the birth defects risk with people residing near the fault zone having higher risk to beget babies with birth defects.