Reference sample method for cardiac output and regional blood flow determinations in the rat.
Reference sample method for cardiac output and regional blood flow determinations in the rat.
复制标题
大鼠心输出量和局部血流量测定的参考样品方法。
DOI：
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发表时间：
1976
影响因子：
3.3
通讯作者：
T. Saba
中科院分区：
文献类型：
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作者：
A. Malik;J. Kaplan;T. Saba
采用参比样品法同时测定清醒大鼠心输出量和局部血流量。将用锶-85标记的微球（直径15 +/-5 μ m）注射到左心室中，并从外周动脉中取出已知体积的参考样品。计算的心输出量测量值与先前报告的大鼠值一致。脑、肠床和肺的心输出量百分比分布与使用较大球体的大鼠中获得的报告值不同。这些差异可能与使用较小的球体和制备方法的差异有关。还测定了以毫升/分钟/克组织重量表示的各器官的绝对区域流量。结果表明，参考样品法可以应用于小型哺乳动物的区域流量和心输出量的测定。
The reference sample method was used for simultaneous determinations of cardiac output and regional blood flows in conscious rats. Microspheres (15 +/- 5 mum in diam) labeled with strontium-85 were injected into the left ventricle and known volumes of reference sample were withdrawn from peripheral arteries. The calculated cardiac output measurements agreed with the previously reported values in rats. The percent distribution of the cardiac output to the brain, intestinal bed, and lungs were different from the reported values obtained in the rats using larger spheres. These differences may be related to the use of smaller spheres and to differences in the preparation. The absolute regional flows to various organs expressed in terms of milliliters per minute per gram tissue weight were also determined. The results indicate that the reference sample method can be applied to smaller mammals for determinations of regional flows and cardiac output.