Development of the Spatial Representation System in the Rat
Development of the Spatial Representation System in the Rat
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DOI：
10.1126/science.1188210
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发表时间：
2010-06-18
期刊：
影响因子：
56.9
通讯作者：
Moser, May-Britt
中科院分区：
文献类型：
--
作者：
Langston, Rosamund F.;Ainge, James A.;Moser, May-Britt
在成人大脑中，空间和方向是由一个复杂的海马-海马旁回路表示的，该回路由头部方向细胞、位置细胞和网格细胞组成。我们报告说，当21周半大的老鼠幼崽第一次探索巢外的开放环境时，已经有了一个基本的空间地图。前耻骨和副耻骨的头向细胞从一开始就具有成体的特性。位置和网格细胞也存在，但进化得更缓慢。网格细胞发育最慢。空间表征的逐渐细化伴随着内嗅星状细胞间网络同步性的增加。在导航开始时出现的成人定向信号提出了这样一种可能性，即这些信号有助于建立位置和网格表示网络。
In the adult brain, space and orientation are represented by an elaborate hippocampal-parahippocampal circuit consisting of head-direction cells, place cells, and grid cells. We report that a rudimentary map of space is already present when 21/2-week-old rat pups explore an open environment outside the nest for the first time. Head-direction cells in the pre- and parasubiculum have adultlike properties from the beginning. Place and grid cells are also present but evolve more gradually. Grid cells show the slowest development. The gradual refinement of the spatial representation is accompanied by an increase in network synchrony among entorhinal stellate cells. The presence of adultlike directional signals at the onset of navigation raises the possibility that such signals are instrumental in setting up networks for place and grid representation.