Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night
Periodic limb movements in sleep exhibit a circadian rhythm that is maximal in the late evening/early night
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DOI：
10.1016/j.sleep.2010.06.007
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发表时间：
2011-01-01
期刊：
影响因子：
4.8
通讯作者：
Winkelman, John W.
中科院分区：
文献类型：
--
作者：
Duffy, Jeanne F.;Lowe, Alex S. W.;Winkelman, John W.
目的：睡眠中的周期性肢体运动（PLMS）表现为夜间模式，大多数运动发生在夜间开始。我们的研究旨在确定这种模式是否是由于内源性的昼夜节律，如在相关的运动障碍不宁腿综合征（RLS）。方法：四个健康的老年人与筛选PLMI > 20进行了研究，在住院强迫desperry协议与强加的睡眠-觉醒周期为20小时的12个“夜晚”，允许分离的昼夜节律和睡眠稳态的影响腿部运动。我们记录睡眠多导睡眠仪在每个预定的情节，包括左，右胫骨前肌EMG.Results：PLMS在第2阶段显示了显着的时间内的睡眠模式和一个显着的昼夜节律。PLMS的昼夜节律达到高峰时，通常的睡眠发作发生在昼夜节律的阶段，在褪黑激素secretory.Conclusions：在我们的主题，PLMs表达的昼夜节律模式是非常相似的，以前报道的RLS患者。PLMS昼夜节律的证据对治疗有影响，并为这种运动障碍的病理生理学的未来研究提供了方向。(C)2010 Elsevier B. V.保留所有权利。
Objective: Periodic limb movements in sleep (PLMS) show a time-of-night pattern, with most movements at the beginning of the night. Our study aimed to determine whether this pattern is due to an endogenous circadian rhythm, like that in the related movement disorder Restless Legs Syndrome (RLS).Methods: Four healthy older adults with a screening PLMI > 20 were studied in an inpatient forced desynchrony protocol with an imposed sleep-wake cycle of 20 h for 12 "nights," allowing separation of circadian and sleep homeostatic influences on leg movements. We recorded sleep polysomnographically throughout each scheduled episode, including left and right anterior tibialis EMG.Results: PLMS in Stage 2 showed both a significant time-within-sleep pattern and a significant circadian rhythm. The circadian rhythm in PLMS peaked at the circadian phases when usual sleep onset occurs, preceding the evening rise in melatonin secretion.Conclusions: In our subjects, the circadian pattern of PLMs expression was very similar to that previously reported in patients with RLS. This evidence for a circadian rhythm in PLMS has implications for treatment and provides direction for future studies of the pathophysiology of this movement disorder. (C) 2010 Elsevier B.V. All rights reserved.