A major histocompatibility complex class I allele shared by two species of chimpanzee
A major histocompatibility complex class I allele shared by two species of chimpanzee
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DOI：
10.1007/s002510050350
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发表时间：
1998-02-01
期刊：
影响因子：
3.2
通讯作者：
Parham, P
中科院分区：
文献类型：
--
作者：
Cooper, S;Adams, EJ;Parham, P
关于自然选择修饰或保留主要组织相容性复合体（MHC）抗原呈递等位基因的速率知之甚少。发现相同的[1101个碱基对（bp）]编码区在MWC类I C基因座在Pan troglodytes和Pan paniscus，黑猩猩物种，分歧类似于230万年前，现在表明，I类同种异型可以生存至少这一时期。显着的保守性也反映在（1799 bp）内含子中，其中最多只有六个取代区分活等位基因（三个来自黑猩猩和两个来自黑猩猩，paniscus），其编码相同的重链同种异型。对一个亲缘关系较远的人类等位基因HLA-Cw*0702的分析证实，内含子变异沿着基因是不均匀的。因此，我们为MHC I类同种异型的寿命提供了一个明确的参考框架，直接估计等位基因置换率，并为MH I类内含子的不寻常进化提供了证据。
Little is known regarding the rates at which natural selection can modify or retain antigen presenting alleles at the major histocompatibility complex (MHC). Discovery of identical [1101 base pairs (bp)] coding regions at the MWC class I C locus in Pan troglodytes and Pan paniscus, chimpanzee species that diverged similar to 2.3 million years ago, now indicates that a class I allotype can survive for at least this period. Remarkable conservation was also reflected in the (1799 bp) introns where a maximum of only six substitutions distinguished live alleles (three from P. troglodytes and two from P., paniscus) that encoded the identical heavy chain allotype. Analysis of a more distantly related human allele, HLA-Cw*0702, corroborated that intron variation was non-uniform along the gene, Thus we provide a clear reference frame for the lifetime of an MHC class I allotype, a direct estimate of allelic substitution rates, and evidence for an unusual evolution of MH(I class I introns.