Low microvessel density is an unfavorable histoprognostic factor in pancreatic endocrine tumors
Low microvessel density is an unfavorable histoprognostic factor in pancreatic endocrine tumors
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DOI：
10.1016/s0016-5085(03)01198-3
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发表时间：
2003-10-01
期刊：
影响因子：
29.4
通讯作者：
Scoazec, JY
中科院分区：
文献类型：
--
作者：
Marion-Audibert, AM;Barel, CC;Scoazec, JY
背景与目的：在许多恶性肿瘤中，肿瘤内微血管密度(MVD)被认为是一个预后参数。我们的目的是对胰腺内分泌肿瘤切除后肿瘤内微血管密度进行定量评估，并评估该参数对预后的潜在意义。方法：对77例患者的82个肿瘤进行研究。CD34免疫组化染色后由2名观察者评估MVD，并与以下参数相关：WHO分类、激素水平、肿瘤大小、血管内皮生长因子表达、有无转移、生存期。结果：MVD为5~92支/视野。分化良好的良性内分泌肿瘤的微血管密度显著高于行为不确定的肿瘤和癌组织。未发现微血管密度与激素水平密切相关。在具有以下组织预后参数特征的肿瘤中，MVD显著较高：大小
Background & Aims: In many malignant tumors, intratumoral microvascular density (MVD) has been suggested to be a prognostic parameter. We aimed to provide a quantitative evaluation of intratumoral microvascular density in a large series of resected endocrine tumors of the pancreas and to evaluate the potential prognostic significance of this parameter. Methods: Eighty-two tumors from 77 patients have been studied. MVD was evaluated by 2 observers after CD34 immunostaining and correlated with the following parameters: WHO classification, hormonal profile, tumor size, vascular endothelial growth factor expression, occurrence of metastasis, duration of survival. Results: MVD ranged from 5 to 92 vessels/field. MVD was significantly higher in well-differentiated benign endocrine tumors than in tumors of uncertain behavior and in carcinomas. No close correlation was found between MVD and the hormonal profile. MVD was significantly higher in tumors characterized by the following histoprognostic parameters: size