Parametric design and correlational analyses help integrating fMRI and electrophysiological data during face processing
Parametric design and correlational analyses help integrating fMRI and electrophysiological data during face processing
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DOI：
10.1016/j.neuroimage.2004.04.018
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发表时间：
2004-08-01
期刊：
影响因子：
5.7
通讯作者：
Gore, JC
中科院分区：
文献类型：
--
作者：
Horovitz, SG;Rossion, B;Gore, JC
面部感知通常与枕下回、上级颞回（STG）和梭状回（FG）中的激活以及与在头皮上峰值约170 ms的枕颞电生理分量N170相关联。然而，N170和神经影像学中观察到的多个面部敏感激活之间的关系尚不清楚。最近已经表明，当高斯噪声被添加到面部的图片时，N170分量的幅度单调地减小[Jemel等人，2003年]。为了帮助澄清N170的来源，而不需要对它们的数量和位置进行先验假设，在同一实验中，在不同的时段记录了5名受试者的ERP和fMRI。我们使用了一个参数化的范例，其中N170的振幅通过改变图片中的噪声水平来调制，并确定了fMRI中信号变化百分比与ERP数据相关的区域。观察到汽车和人脸图片的N170信号，但人脸的N170信号更强。在右半球部位观察到N170随噪声增加而单调下降，但在左半球和枕叶中心部位不太清楚。双侧梭状回和上级颞回的fMRI信号与N170波幅的相关性非常显著（P < 0.001）。对于汽车，在海马旁区和STG中观察到最强的相关性（P < 0.005）。除了有助于澄清的时空过程中的面孔处理，这项研究说明了如何ERP信息可以协同使用的功能磁共振成像分析。参数设计可以进一步发展，以提供一些fMRI活动的时序信息，并帮助识别ERP信号的发生器。(C)2004年爱思唯尔公司All rights reserved.
Face perception is typically associated with activation in the inferior occipital, superior temporal (STG), and fusiform gyri (FG) and with an occipitotemporal electrophysiological component peaking around 170 ms on the scalp, the N170. However, the relationship between the N170 and the multiple face-sensitive activations observed in neuroimaging is unclear. It has been recently shown that the amplitude of the N170 component monotonically decreases as gaussian noise is added to a picture of a face [Jemel et al., 2003]. To help clarify the sources of the N170 without a priori assumptions regarding their number and locations, ERPs and fMRI were recorded in five subjects in the same experiment, in separate sessions. We used a parametric paradigm in which the amplitude of the N170 was modulated by varying the level of noise in a picture, and identified regions where the percent signal change in fMRI correlated with the ERP data. N170 signals were observed for pictures of both cars and faces but were stronger for faces. A monotonic decrease with added noise was observed for the N170 at right hemisphere sites but was less clear on the left and occipital central sites. Correlations between fMRI signal and N170 amplitudes for faces were highly significant (P < 0.001) in bilateral fusiform gyrus and superior temporal gyrus. For cars, the strongest correlations were observed in the parahippocampal region and in the STG (P < 0.005). Besides contributing to clarify the spatiotemporal course of face processing, this study illustrates how ERP information may be used synergistically in fMRI analyses. Parametric designs may be developed further to provide some timing information on fMRI activity and help identify the generators of ERP signals. (C) 2004 Elsevier Inc. All rights reserved.