Perivascular Adipose Tissue Compensation for Endothelial Dysfunction in the Superior Mesenteric Artery of Female SHRSP.Z-Leprfa/IzmDmcr Rats
Perivascular Adipose Tissue Compensation for Endothelial Dysfunction in the Superior Mesenteric Artery of Female SHRSP.Z-Leprfa/IzmDmcr Rats
复制标题
DOI：
10.1159/000524187
复制
发表时间：
2022-04-29
影响因子：
1.7
通讯作者：
Shinozuka，Kazumasa
中科院分区：
文献类型：
--
作者：
Kagota，Satomi;Futokoro，Risa;Shinozuka，Kazumasa
血管周围脂肪组织（PVAT）对动脉张力的调节在性别上是不同的。在男性SHRSP中。Z-Lepr fa/IzmDmcr大鼠(SHRSP。ZF)， PVAT对代谢综合征早期发生的内皮介导的血管松弛丧失具有代偿性松弛作用。然而，这种效果在23周龄时就会减弱。因此，在这里，我们比较了PVAT对女性和男性SHRSP的影响。ZF。乙酰胆碱诱导的无PVAT的肠系膜上动脉松弛在23周龄雌、雄鼠之间没有差异。然而，PVAT的存在增强了23周龄女性的放松，但在男性中没有。PVAT中血管紧张素II型1受体（AT1R） mRNA水平在性别间无差异，但AT1R相关蛋白（ATRAP）和apelin水平在女性中高于男性。我们观察到有和没有PVAT和ATRAP或apelin mRNA水平的动脉舒张差异呈正相关。与23周龄相比，30周龄雌鼠pvat增强的松弛消失，AT1R mRNA水平升高，而apelin水平下降。这些结果表明，在SHRSP。ZF， PVAT对内皮功能障碍的代偿在女性中比在男性中延伸到更大的年龄。Apelin和AT1R/ATRAP在PVAT中的表达可能是有利效应的预测因子。
Regulation of arterial tone by perivascular adipose tissue (PVAT) differs between sexes. In male SHRSP. Z-Lepr fa/IzmDmcr rats (SHRSP. ZF), PVAT exerts a compensatory relaxation effect for the loss of endothelium-mediated vasorelaxation, which occurs during the early stages of metabolic syndrome. However, this effect deteriorates by 23 weeks of age. Here, therefore, we compared the effects of PVAT in female and male SHRSP. ZF. Acetylcholine-induced relaxation in superior mesenteric artery without PVAT did not differ between 23-week-old females and males. However, the presence of PVAT enhanced relaxation in 23-week-old females, but not in males. The mRNA levels of angiotensin II type 1 receptor (AT1R) in PVAT did not differ between sexes, but AT1R-associated protein (ATRAP) and apelin levels were higher in females than in males. We observed a positive relationship between differences in artery relaxation with and without PVAT and ATRAP or apelin mRNA levels. In 30-week-old females, PVAT-enhanced relaxation disappeared, and mRNA levels of AT1R increased, while apelin levels decreased compared to 23-week-old females. These results demonstrated that in SHRSP. ZF, PVAT compensation for endothelium dysfunction extended to older ages in females than in males. Apelin and AT1R/ATRAP expression in PVAT may be predictors of favorable effects.