Vulnerability to depression: a moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds.
Vulnerability to depression: a moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds.
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DOI：
10.1017/s0954579413000047
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发表时间：
2013-08
影响因子：
3.3
通讯作者：
Crick NR
中科院分区：
文献类型：
--
作者：
Banny AM;Cicchetti D;Rogosch FA;Oshri A;Crick NR
儿童虐待、同伴受害和5-羟色胺转运基因多态性（5-HTTLPR）作为抑郁症状的预测因子进行了研究。儿童（M年龄= 11.26,SD = 1.65），包括156名受虐待儿童和145名来自可比较的低社会经济背景的未受虐待儿童，提供了DNA样本和关系同伴受害、明显同伴受害和抑郁症状的自我报告。通径分析显示，关系性受害和显性受害在儿童虐待与抑郁症状之间起中介作用。使用引导程序来测试调节中介，并证明基因型调节了关系和显性受害对儿童抑郁症状的间接影响，例如，与携带s等位基因的受害儿童相比，携带l/l变异的受害儿童患抑郁症状的风险增加。结果强调了研究过程模型的实用性，该模型结合了促进抑郁症状学发展的生物和心理因素，并从多层次的分析方法中为理解和促进高风险青少年的恢复力提供了方向。
Child maltreatment, peer victimization, and a polymorphism of the serotonin transporter gene (5-HTTLPR) were examined as predictors of depressive symptomatology. Children (M age = 11.26, SD = 1.65), including 156 maltreated and 145 nonmaltreated children from comparable low socioeconomic backgrounds, provided DNA samples and self-reports of relational peer victimization, overt peer victimization, and depressive symptoms. Path analysis showed that relational and overt victimization mediated the association between child maltreatment and depressive symptoms. Bootstrapping procedures were used to test moderated mediation and demonstrated that genotype moderated the indirect effects of relational and overt victimization on child depressive symptoms, such that victimized children with the l/l variation were at an increased risk for depressive symptoms compared to victimized children carrying an s allele. Results highlight the utility of examining process models that incorporate biological and psychological factors contributing to the development of depressive symptomatology, and provide direction toward understanding and promoting resilience among high risk youth from a multiple levels of analysis approach.