The influence of the epidermis and other tissues on blood vessel growth in the hamster cheek pouch.
The influence of the epidermis and other tissues on blood vessel growth in the hamster cheek pouch.
复制标题
表皮和其他组织对仓鼠颊囊血管生长的影响。
DOI：
10.1111/1523-1747.ep13077211
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
T. Ryan
中科院分区：
文献类型：
--
作者：
K. Nishioka;T. Ryan
为了证明表皮对血管的影响，将新生仓鼠的各种组织用微孔过滤器包裹起来，移植到仓鼠的面颊囊腔中。表皮、颊膜和肺可诱导新生血管的生长，而心肌、真皮和其他组织则不能。新的毛细血管在微孔过滤器上形成环状生长，包围着移植的表皮，但永远不会覆盖它。它们相互吻合，形成了一个网络：类似于在正常人类皮肤上看到的。肺移植周围仅发现不完全的毛细血管生长。新生的毛细血管生长在颊周膜周围的血管膜侧。本实验提出了至少三种表皮对血管的影响：a)刺激新生血管的生长，b)支架的形成使毛细血管爬过微孔滤膜，c)屏障的形成以防止血管侵入表皮。
In order to demonstrate an epidermal influence on blood vessels various tissues from neonatal hamsters, enclosed by Millipore filters, were transplanted into hamster cheek pouch chambers. Epidermis, buccal membrane and lung induced new vessel growth, while heart muscle, dermis and other tissues did not. The new capillaries grew as loops over the Millipore filter to surround the epidermal transplant but never to cover it. They anastomosed with each other and formed a network: similar to that seen in normal human skin. Only incomplete capillary growth was noted around the lung transplant. New capillary growth was prominent at the vascular membrane side around buccal membrane. At least three kinds of epidermal influence on blood vessels were suggested by this experiment: a) stimulation of new vessel growth, b) scaffold formation for the capillaries to climb up over the Millipore filter, and c) barrier formation to prevent vessel invasion into the epidermis.