ESTROGEN MODULATES INHIBITORY CONTROL IN HEALTHY HUMAN FEMALES: EVIDENCE FROM THE STOP-SIGNAL PARADIGM
ESTROGEN MODULATES INHIBITORY CONTROL IN HEALTHY HUMAN FEMALES: EVIDENCE FROM THE STOP-SIGNAL PARADIGM
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DOI：
10.1016/j.neuroscience.2010.02.029
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发表时间：
2010-05-19
期刊：
影响因子：
3.3
通讯作者：
Hommel, B.
中科院分区：
文献类型：
--
作者：
Colzato, L. S.;Hertsig, G.;Hommel, B.
动物研究指出雌激素在解释纹状体多巴胺能功能的性别差异中的作用，但仍然缺乏来自人类研究的证据。鉴于多巴胺对控制和组织目标导向行为至关重要，雌激素可能对认知控制功能产生特定影响，例如抑制优势反应。我们比较了年轻女性在月经周期的三个阶段（评估唾液雌二醇和孕酮浓度）和年轻男性的抑制控制效率（通过停止信号任务测量）。女性在卵泡期抑制优生反应的效率较低，这与较高的雌二醇水平和较高的多巴胺周转率有关，而不是在黄体期或月经期。同样，女性在卵泡期表现出比男性更低的有效抑制控制，但在黄体期或月经期则没有。我们的研究结果是一致的模型假设，在卵泡期纹状体多巴胺的过度供应削弱抑制通路，从而导致反应之间的竞争增强。我们的结论是反应抑制的性别差异是可变的和状态依赖的，但不是结构性的。(C)2010年IBRO。由爱思唯尔有限公司出版。保留所有权利。
Animal studies point to a role of estrogen in explaining gender differences in striatal dopaminergic functioning, but evidence from human studies is still lacking. Given that dopamine is crucial for controlling and organizing goal-directed behavior, estrogen may have a specific impact on cognitive control functions, such as the inhibition of prepotent responses. We compared the efficiency of inhibitory control (as measured by the stop-signal task) in young women across the three phases of their menstrual cycle (salivary estradiol and progesterone concentrations were assessed) and in young men. Women were less efficient in inhibiting prepotent responses in their follicular phase, which is associated with higher estradiol levels and with higher dopamine turnover rates, than in their luteal or menstruation phase. Likewise, women showed less efficient inhibitory control than men in their follicular phase but not in their luteal or menstruation phase. Our results are consistent with models assuming that the over-supply of striatal dopamine in the follicular phase weakens inhibitory pathways, thus leading to enhanced competition between responses. We conclude that gender differences in response inhibition are variable and state dependent but not structural. (C) 2010 IBRO. Published by Elsevier Ltd. All rights reserved.