BMI-1 is highly expressed in MO-subtype acute myeloid leukemia
BMI-1 is highly expressed in MO-subtype acute myeloid leukemia
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DOI：
10.1532/ijh97.05013
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发表时间：
2005-07-01
影响因子：
2.1
通讯作者：
Naoe, T
中科院分区：
文献类型：
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作者：
Sawa, M;Yamamoto, K;Naoe, T
最近的研究表明，polycomb组基因之一BMI-1通过抑制INK 4a/ARFlocus在正常和白血病干细胞的维持中具有重要作用。在这里，我们定量检测了急性髓细胞白血病（AML）和其他血液恶性肿瘤患者样本中BMI-1的表达水平。在AML患者中检测到中度至高度BMI-1表达，并且AML样品中的BMI-1表达水平显著高于正常骨髓对照（P =.0011）。法国-美国-英国分类的MO亚型标本显示BMI-1转录本的相对表达（中位数，390.2 × 10 - 3）高于其他亚型（中位数，139.0 × 10-3）（p
Recent studies have suggested that one of the polycomb group genes, BMI-1, has an important role in the maintenance of normal and leukemic stem cells by repressing the INK4a/ARFlocus. Here, we quantitatively examined BMI-1 expression level in samples from patients with acute myeloid leukemia (AML) and other hematologic malignancies. Moderate to high BMI-1 expression was detected in AML patients, and the BMI-1 expression levels in AML samples were significantly higher than in normal bone marrow controls (P =.0011). Specimens of French-American-British classification subtype MO showed higher relative expression of the BMI-1 transcript (median, 390.2 X 10(-3)) than the other subtypes (median, 139.0 X 10-3) (p