A Randomized Intervention of Reminder Letter for Human Papillomavirus Vaccine Series Completion
A Randomized Intervention of Reminder Letter for Human Papillomavirus Vaccine Series Completion
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DOI：
10.1016/j.jadohealth.2014.08.014
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发表时间：
2015-01-01
影响因子：
7.6
通讯作者：
Xu, Lanfang
中科院分区：
文献类型：
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作者：
Chao, Chun;Preciado, Melissa;Xu, Lanfang
目的：三剂系列人乳头瘤病毒 (HPV) 疫苗的完成率普遍较低。本研究评估了提醒信干预对 HPV 疫苗三剂系列完成的有效性。方法：纳入了 Kaiser Permanente 南加州健康计划的女性成员，她们在 2013 年 2 月 13 日之前接受了至少一剂、但不超过两剂 HPV 疫苗，且首次接种 HPV 疫苗时年龄在 9 至 26 岁之间。其中 80% 的女性被随机分配接收提醒信，20% 的女性被随机分配接受标准护理（对照）。提醒信每季度邮寄给那些尚未完成该系列的人。使用卡方检验比较 12 个月评估期结束时系列完成的比例。结果：干预组总共包括 9,760 名女性，对照组包括 2,445 名女性。干预组 HPV 疫苗系列完成率为 56.4%，对照组为 46.6% (p < .001)。与 18-26 岁的年轻女性相比，首次接种干预措施的效果似乎在 9-17 岁的女孩中更强，在黑人中的效果似乎比白人更强。结论：每季度安排的提醒信可有效提高开始接种疫苗的人的 HPV 疫苗系列的完成情况。然而，尽管进行了干预，系列完成率仍然存在很大差距。未来的研究应该解决系列完成的其他障碍，包括提供者和医疗保健系统层面的障碍。 (C) 2015 年青少年健康与医学协会。版权所有。
Purpose: Completion rate for the three-dose series of the human papillomavirus (HPV) vaccine has generally been low. This study evaluated the effectiveness of a reminder letter intervention on HPV vaccine three-dose series completion.Methods: Female members of Kaiser Permanente Southern California Health Plan who received at least one dose, but not more than two doses, of the HPV vaccine by February 13, 2013, and who were between ages 9 and 26 years at the time of first HPV vaccination were included. Eighty percent of these females were randomized to receive the reminder letter, and 20% were randomized to receive standard of care (control). The reminder letters were mailed quarterly to those who had not completed the series. The proportion of series completion at the end of the 12-month evaluation period was compared using chi-square test.Results: A total of 9,760 females were included in the intervention group and 2,445 in the control group. HPV vaccine series completion was 56.4% in the intervention group and 46.6% in the control groups (p < .001). The effect of the intervention appeared to be stronger in girls aged 9-17 years compared with young women aged 18-26 years at the first dose and in blacks compared with whites.Conclusions: Reminder letters scheduled quarterly were effective to enhance HPV vaccine series completion among those who initiated the vaccine. However, a large gap in series completion remained despite the intervention. Future studies should address other barriers to series completion, including those at the providers and the health care system level. (C) 2015 Society for Adolescent Health and Medicine. All rights reserved.